Effect of , and gene polymorphisms on the efficiency and safety of postoperative analgesia with ketoprofen.

Objectives: Patients undergoing cardiac surgery develop post-sternotomy pain syndrome. The aim of this study was evaluation of the influence of , and genes polymorphisms on the efficacy and safety of postoperative analgesia with ketoprofen in patients with coronary artery disease after cardiac surgery.

Methods: The study included 90 patients undergoing cardiac surgery.

Effects of polymorphisms on the efficacy and safety of amlodipine therapy in Caucasian patients with stage I-II hypertension.

Purpose: The aim of this study was to determine the impact of (MDR1) polymorphisms on the efficacy and safety of amlodipine in Caucasian patients.

Patients And Methods: The 12-week study included 100 patients. Patients with the newly diagnosed stage I-II hypertension (HT) were recruited to complete genotyping of the single-nucleotide polymorphism (SNP).