Publications by authors named "Nadezhda E Shchepina"
Article Synopsis
- A dermatophyte called (Bodin, 1902) poses a risk, especially to immunosuppressed patients, prompting the need for new antifungal treatments.
- Previous research identified certain phenylbenzoquinaldinium derivatives with antifungal activity, leading to the exploration of arylbenzoquinaldinium derivatives in this study.
- The compound phenyl-[f]-benzoquinaldinium tetrafluoroborate demonstrated strong antifungal effects, potentially surpassing existing medications, and has applications for further biological studies as a radiotracer.
Background: The nuclear-chemical method brought unique opportunity for synthesis of unknown and hardly available organic compounds. Presence of tritium labeling allows one-step preparation of radioactive markers for the investigation of chemical and biological processes.
Methods: The ion-molecular reactions of nucleogenic phenyl cations with 4-picoline have been carried out.
Comparison of ion-molecular reactions of free-phenyl cations generated by tritium β -decay with 2-methyl- and 2-phenylquinolines has been investigated. The reaction of direct nitrogen atom phenylation with the help of nucleogenic phenyl cations has been fulfilled for the first time and a new one-step synthesis of tritium-labeled N-phenyl-2-phenylquinolinium salt-lipophilic radioactive biological marker has been elaborated.
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