Evaluating the antibacterial activity of engineered phage ФEcSw endolysin against multidrug-resistant Escherichia coli strain Sw1.

Objective: The emergence of bacteriophage-encoded endolysins hold significant promise as novel antibacterial agents, particularly against the growing threat of antibiotic-resistant bacteria. Therefore, we investigated the phage ФEcSw endolysin to enhance the lytic activity against multi-drug-resistant Escherichia coli Sw1 through site-directed mutagenesis (SDM) guided by in silico identification of critical residues.

Methods: A computational analysis was conducted to elucidate the protein folding pattern, identify the active domains, and recognize critical residues of ФEcSw endolysin.

The Effect of Simulated Physiological Oocyte Maturation (SPOM) and L-Carnitine on Bovine Oocyte Developmental Competence.

Background: Simulated Physiological Oocyte Maturation (SPOM) mimics the physiological events of oocyte maturation in the presence of cAMP modulators. These modulators increase the intracellular concentrations of cAMP, which inhibits the immediate resumption of meiosis and gives the oocyte more time to gain optimal developmental competence. In addition, L-carnitine helps to increase the energy supply of cells through the β-oxidation of fatty acids.

Graphene-Loaded Aphron Microbubbles for Enhanced Drilling Fluid Performance and Carbon Capture and Storage.

Maintaining the stability of microbubbles is essential for enhancing the longevity of aphronic water-based drilling fluid usage in drilling depleted reservoirs and other under-pressured zones. Here, we introduce the integration of partially reduced graphene oxide (PrGO) nanosheets into the shell of aphron microbubbles (AMBS) to enhance the stability and size distribution, particularly for drilling fluid applications and carbon geological storage. The amphiphilic characteristic of PrGO nanosheets, due to meticulous control of the reduction process of graphene oxide, facilitates their spontaneous adsorption at interfaces, thereby reducing the interfacial energy as a two-dimensional surfactant.

Combined effect of compressing fresh concrete and curing regime on bonding performance of high strength repair mortar.

High strength concrete (HSC) is highly appropriate for the retrofitting and rehabilitation of reinforced concrete structures due to its low permeability and high bonding strength. However, its low workability and sensitivity to curing conditions pose significant challenges for its implementation in such projects. This study introduces a novel technique to overcome the workability barrier of HSC while enhancing its bonding strength under various curing conditions.

Mindfulness and Readiness to Change in Individuals with Substance Abuse: The Mediating Role of Self-Compassion and Striving to Compensate for Inferiority.

Background: Motivation and readiness to change are critical first steps in preventing relapse into substance dependence. Therefore, examining their antecedents is essential for effective therapeutic interventions. This study aimed to investigate the relationship between self-compassion, mindfulness, striving to compensate for inferiority, and readiness to change in individuals with substance abuse.

Effects of intravenous tranexamic acid on bleeding during burn surgery: A double-blinded randomized clinical trial.

Blood loss during burn surgery significantly contributes to morbidity and mortality. Tranexamic acid (TXA), an antifibrinolytic agent, is hypothesized to reduce intraoperative bleeding. This double-blinded, randomized clinical trial aimed to assess the efficacy of systemic TXA in severe burn patients (total body surface area [TBSA] > 20 %) undergoing surgery.

Host and Viral Factors Influencing Chronic Hepatitis B Infection Across Three Generations in a Family.

Chronic hepatitis B (CHB) infection is influenced by both virological and host factors. A total of 5,920 CHB patients were classified into four groups based on HBV seromarkers: three-generation families (CHB grandmother, mother, and child), two-generation families (CHB mother/child pairs), individuals recovered from HBV infection, and a control group. Serological markers, viral load, liver function tests (LFT), HBV mutations, HLA-DQ variations, cytokine polymorphisms, and liver stiffness measurements (LSM) were analyzed using FibroScan.

The extraction of inorganic phase-change materials from sugar industry wastes with the purpose of solid waste management.

This study focused on the feasibility of identifying and recycling inorganic phase-change materials (PCMs) from sugar industry wastes in two cities of Qazvin and Hamadan in Iran. In this study, dry sugar beet pomace, sugar beet pomace, sugar beet molasses, leaves and plant residues of sugar beet and sugarcane bagasse were investigated. The inorganic materials were identified by X-ray Diffraction (XRD), thermal characteristics were determined by differential scanning calorimetry (DSC), and morphological characteristics were determined by scanning electron microscopy (SEM).

Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions.

During postnatal brain development, maintaining a delicate balance between excitation and inhibition (E/I) is essential for the precise formation of neuronal circuits. The K+/cl- cotransporter 2 (KCC2) is instrumental in this process, and its dysregulation is implicated in various neurological disorders. This study utilized zebrafish () to investigate the socio-cognitive consequences of KCC2 disruption.

Performance trend of the family physician referral system before and during the COVID-19 pandemic: a study in northern Iran.

Background: Considering the challenges of the referral system in the family physician program and the impact of COVID-19 pandemic on the performance of the relevant ministry's programs, it is necessary to assess the performance of the referral system. This study was conducted with the aim of investigating the performance of the family physician referral system before and during COVID-19 in Golestan province.

Methods: The present repeated cross-sectional study was conducted on secondary data Recorded of 786,603 cases referred and cared by family physicians (including information on physicians' and midwives' visits, percentage of prescriptions and other information) in Golestan province from 2017 to 2022 in a census and retrospective manner.

Evaluation of the qualitative properties of the oil extracted from the mixture of Helianthus annuus and Nigella sativa seeds during heating.

The oil obtained from black cumin (Nigella sativa) seeds has many health-effective properties, which is used in food applications and in traditional medicine. One practical method to extract its oil is mixing with other seeds such as sunflower (Helianthus anuus) seeds before oil extraction by press. The effectiveness of the cold-press oil obtained from the mixture of black cumin seeds (BS) and sunflower seeds (SF) in different proportions 100:0, 95:5, 90:10, 85:15 and 0:100 (w/w) was studied to evaluate their qualitative properties including peroxide value (PV), acid value, p-anisidine value (AnV), pigments (carotenoid and chlorophyll) content, polyphenols, and profile of fatty acids during heating process (30-150 min at 180 °C).

Experimental and CFD analysis of fluid flow through nanofiber filter media.

This work presents a novel approach to investigating the slip effect in nanofiber filter media. Electrospun nanofiber media with high efficiency and low pressure drop were produced at different concentrations and durations. The surface and cross-sectional morphology of nanofiber media were studied using FE-SEM.

The relationship between demographic factors and known risk factors with breast cancer in women aged 30-69.

Background: Breast cancer is one of the most important causes of cancer deaths in women. The present study was conducted to determine the relationship between demographic factors and known risk factors with breast cancer in women aged 30-69.

Method: This case-control study was conducted with two matched and unmatched control groups.

Therapeutic effects of olfactory training and systemic vitamin A in patients with COVID-19-related olfactory dysfunction: a double-blinded randomized controlled clinical trial.

Objectives: The new corona virus infection, has a wide range of clinical manifestations. Fever and cough are the most common symptoms. The olfactory function may be also affected with COVID-19.

Rapeseed oleogels based on monoacylglycerols and methylcellulose hybrid oleogelators: Physicochemical and rheological properties.

In this study, we investigated the combined impact of monoacylglycerol (MAGs) and methylcellulose (MC) on the production of hybrid oleogels. Since cellulose derivatives are inherently hydrophilic substances, they require dissolution in oil through an emulsion-coating method. Therefore, we developed a hybrid oleogel utilizing MAGs and MC.

Outpatient Cardiovascular Rehabilitation Registry in Iran: The First Rehabilitation Registry Experience at EMR.

Introduction: The collected information includes demographic profile, medical history, physical examination, patient risk factors, anthropometric evaluation, medications, echocardiographic results, and exercise testing of all patients who participated in the outpatient cardiac rehabilitation program in Cardiac Rehabilitation Department since 1996 until now. Each patient was assigned an electronic code by which the patient's information could be identified. Subsequently, standard questionnaires were used, such as International physical activity questionnaire (IPAQ) to assess physical activity, MAC NEW to assess the quality of life, Spielberg to measure anxiety, Beck to assess depression, and nutritional questionnaires.

Little associations exist between the three commonly used functional screening tests in collegiate athletes.

Although an abundant number of studies have investigated the predictability of the commonly used functional screening tests and despite their popularity and applicability, the relationships between these tests have rarely been studied and have not been well established. This study aimed to examine the potential association between the Functional Movement Screen (FMS), Y Balance Test (YBT), and Landing Error Scoring System (LESS). Six hundred twenty-seven Iranian collegiate athletes (347 males, age = 22.

Biochemical properties and pigment contents of genotypes affected by plant growth regulators and temperature stress.

There is little data, to our knowledge, on the biochemical properties of different sp. genotypes affected by plant growth regulators (PGR) under temperature stress. A split plot research on the basis of a complete randomized block design with three replicates examining temperature stress (planting dates, 8th of April, May and June) (main factor), and the factorial combination of plant growth regulators (PGR, control (CO), gibberellic acid (GA), fertilization (MI), and amino acid (A)), and genotypes (Khuzestani, Mutika, and Bakhtiari) on plant biochemical properties, was conducted.

Understanding Creutzfeldt-Jakob disease in Iran: a systematic review of case reports.

Objective: To systematically review the reported cases of Creutzfeldt-Jakob disease (CJD) in Iran.

Methods: A comprehensive literature review of CJD cases in Iran was undertaken using the PubMed®, Scopus® and Google Scholar databases. In addition, the Iranian database MagIran was searched for Persian language reports.

Effect of Intra-ovarian Injection of Mesenchymal Stem Cells or its Conditioned Media on Repeated OPU-IVEP Outcomes in Jersey Heifers and Its Relationship with Follicular Fluid Inflammatory Markers.

Background: Repeated Ovum Pick Up (OPU) could have a detrimental effect on ovarian function, reducing Embryo Production (IVEP). The present study examined the therapeutic effect of adipose-derived Mesenchymal Stem Cells (MSCs) or its Conditioned Medium (ConM) on ovarian trauma following repeated OPU. Resolvin E1 (RvE1) and Interleukin-12 (IL-12) were investigated as biomarkers.