The Assessment of Toxicity Characteristics of Cellular Uptake of Paramagnetic Nanoparticles as a New Magnetic Resonance Imaging Contrast Agent.

Nanoparticles are unique that enable many promising medical and technological applications in their physical, and chemical properties. It is widely accepted that nanoparticles should be thoroughly tested for health nanotoxicity, but a moderate risk analysis is currently prevented by a revealing absence of mechanistic knowledge of nanoparticle toxicity. The purpose of this study was to assess cytotoxicity of Gadolinium oxide with diethylene glycol polymer (GdO-DEG) and magneto liposome nanoparticles (MLNs) in Hepa 1-6 cell lines as models to assess nanotoxicity .

Theranostic α-Lactalbumin-Polymer-Based Nanocomposite as a Drug Delivery Carrier for Cancer Therapy.

A nanotheranostic system was developed using α-lactalbumin along with FeO nanoparticles as an magnetic resonance imaging (MRI) contrast agent for medical imaging and doxorubicin as the therapeutic agent. α-lactalbumin was precipitated and cross-linked using poly(ethylene glycol) and glutaraldehyde. Besides, polyethylenimine was applied to increase the number of amine groups during cross-linking between α-lactalbumin and FeO nanoparticles.