Publications by authors named "Nadejda M Pleskach"
Int J Mol Sci
January 2022
Article Synopsis
- The study compares how full-length PML isoforms and their C-terminal domains form PML bodies with and without endogenous PML, identifying key characteristics of these structures.
- Findings show that full-length PML isoforms can independently create dynamic liquid-droplet compartments, while only specific C-terminal domains (of PML-II and PML-V) can incorporate into endogenous PML bodies.
- Moreover, alterations like the K490R substitution affect the distribution of these domains in cells, emphasizing the importance of disordered regions in facilitating liquid-liquid phase separation, regardless of the presence of structured N-terminal motifs.
