A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer.

Apoptosis is essential for chemotherapy responses. In this discovery and validation study, we evaluated the suitability of a mathematical model of apoptosis execution (APOPTO-CELL) as a stand-alone signature and as a constituent of further refined prognostic stratification tools. Apoptosis competency of primary tumor samples from patients with stage III colorectal cancer ( = 120) was calculated by APOPTO-CELL from measured protein concentrations of Procaspase-3, Procaspase-9, SMAC, and XIAP.