Plasma Cell Leukaemia: A Rare Yet Aggressive Plasma Cell Dyscrasia With A Very Poor Response To Conventional Therapy.

Plasma cell leukaemia (PCL) is a very rare plasma cell dyscrasia with a significant number of monoclonal plasma cells in the peripheral blood. It is diagnosed by the presence of ≥ 2x109 /L plasma cells in the blood or by plasma cells making up ≥20% of the leukocyte count. It can arise from a leukemic transformation of multiple myeloma, or more commonly it can be primary.

Design and Mechanistic Study of Highly Durable Carbon-Coated Cobalt Diphosphide Core-Shell Nanostructure Electrocatalysts for the Efficient and Stable Oxygen Evolution Reaction.

The facile synthesis of hierarchically functional, catalytically active, and electrochemically stable nanostructures holds a tremendous promise for catalyzing the efficient and durable oxygen evolution reaction (OER) and yet remains a formidable challenge. Herein, we report the scalable production of core-shell nanostructures composed of carbon-coated cobalt diphosphide nanosheets, C@CoP, via three simple steps: (i) electrochemical deposition of Co species, (ii) gas-phase phosphidation, and (iii) carbonization of CoP for catalytic durability enhancement. Electrochemical characterizations showed that C@CoP delivers an overpotential of 234 mV, retains its initial activity for over 80 h of continuous operation, and exhibits a fast OER rate of 63.

A Presentation of Twiddler's Syndrome with Underlying Ratchet Mechanism.

Twiddler's syndrome, reel syndrome, and ratchet phenomenon are rare causes of pacemaker lead displacement. The presentation of Twiddler's syndrome with underlying ratchet mechanism is quite rarely reported in literature. In this case report we present a 63-year-old male with a history of non-ischemic cardiomyopathy who had his biventricular implantable cardioverter defibrillator leads dislodged and presented as sub-acute exacerbation of heart failure.

Antioxidant potential of a soft cheese (paneer) supplemented with the extracts of date (Phoenix dactylifera L.) cultivars and its whey.

Objective: The present study was conducted to evaluate the antioxidant potential of paneer, a soft cheese supplemented with various water soluble date extracts during storage. Further, the whey obtained from all the paneer samples was also investigated for its antioxidant potential.

Methods: The date cultivars were evaluated for their physico-chemical characteristics and date extracts were assessed for their antioxidant potential.

A rare case of osteomyelitis of the clavicle in a child due to Group A streptococcal infection.

Acute osteomyelitis of the clavicle is rare in the paediatric age group. We treated a 5-year-old boy who presented initially with fever and left shoulder pain, and subsequently developed swelling in the region of the left clavicle. Group A (GAS) was isolated in blood culture.

Toxicological potential of cobalt in forage for ruminants grown in polluted soil: a health risk assessment from trace metal pollution for livestock.

The trace metal pollution in the environment is a highly concerned issue in these days. One of the important causes of trace metal pollution is the exhaust gases released from the vehicles on the roads. These dangerous gases pose life-threatening effects on the forage plants grown along the roadside as these plants are at direct risk to these trace metals.

The antioxidant components of milk and their role in processing, ripening, and storage: Functional food.

The current rate of population growth is so fast that, to feed this massive population, a 2-fold increase in land is required for the production of quality food. Improved dietary products such as milk and its products with antioxidant properties and functional foods of animal origin have been utilized to prevent chronic diseases. The designer milk contains low fat and less lactose, more protein, modified level of fatty acids, and desired amino acid profiles.

A trinuclear cobalt-based coordination polymer as an efficient oxygen evolution electrocatalyst at neutral pH.

The dearth of an efficient, robust, abundant and cost-effective water oxidation catalyst is debatably the major hurdle for the technological advancement of artificial photosynthesis devices. Herein, a three dimensional (3D) cobalt-based coordination polymer {[Co(pyz)(fa)(dmso)]·2HO}, (1) (pyz = pyrazine, fa = fumarate, dmso = dimethyl sulfoxide) has been synthesized and demonstrated to act as an efficient electrocatalyst towards water oxidation at neutral pH. Compound 1 displays a stair-like arrangement parallel to the b-axis, with the cobalt clusters arranged in a zigzag fashion, and contains small, honeycomb-like channels parallel to the c-axis.

Health Related Quality of Life (HRQOL) and its correlation with academic performance of medical students.

Objective: To determine health related quality of life (HRQOL) of medical students and its correlation with their academic performance.

Methods: Cross sectional study at Services Institute of Medical Sciences, included students of 4 and final year MBBS, who filled SF-36 proforma of HRQOL. Scores of 8-domains and of physical component and mental component summary were determined.

Triglyceride, fatty acid profile and antioxidant characteristics of low melting point fractions of Buffalo Milk fat.

Background: Among the dietary lipids, milk fat is most complicated as it contains more than one hundred types of fatty acids and several triglycerides. Huge versatility in triglyceride and fatty composition makes it possible to convert milk fat into various fractions on the basis of melting characteristics. Functional properties of milk fat can be increased by converting it into different fractions.

Probing the storage stability and sensorial characteristics of wheat and barley grasses juice.

The present research study was designed for the development of functional drinks from wheat and barley grasses followed by their physicochemical and sensorial characterization. In 1st phase, wheatgrass and barley grass juices were prepared with different concentrations and were subjected for physicochemical analysis and sensorial evaluation. Moreover, these juices were analyzed for color indices, pH, acidity, and total soluble solids (TSS) during storage study at 0, 2, 4, and 6 days.

Biochemical and in silico evaluation of recombinant E. coli aminopeptidase and in vitro processed human interferon α-2b.

Escherichia coli is an extensively used host for the production of recombinant proteins, making its N-terminal methionine aminopeptidase (MAP) an attractive candidate for studies on posttranslational protein processing. The present study describes the recombinant production and properties of MAP from the DH5α strain of E. coli.

Mobile genomic element diversity in world collection of safflower (Carthamus tinctorius L.) panel using iPBS-retrotransposon markers.

Safflower (Carthamus tinctorius L.) is a multipurpose crop of dry land yielding very high quality of edible oil. Present study was aimed to investigate the genetic diversity and population structure of 131 safflower accessions originating from 28 different countries using 13 iPBS-retrotransposon markers.

Luteolin, a flavonoid, as an anticancer agent: A review.

Many food-derived phytochemicals and their derivatives represent a cornucopia of new anti-cancer compounds. Luteolin (3,4,5,7-tetrahydroxy flavone) is a flavonoid found in different plants such as vegetables, medicinal herbs, and fruits. It acts as an anticancer agent against various types of human malignancies such as lung, breast, glioblastoma, prostate, colon, and pancreatic cancers.

Grain Legumes and Fear of Salt Stress: Focus on Mechanisms and Management Strategies.

Salinity is an ever-present major constraint and a major threat to legume crops, particularly in areas with irrigated agriculture. Legumes demonstrate high sensitivity, especially during vegetative and reproductive phases. This review gives an overview of legumes sensitivity to salt stress (SS) and mechanisms to cope with salinity stress under unfavorable conditions.

Assessing and Reporting Household Chemicals as a Novel Tool to Mitigate Pesticide Residues in Spinach (Spinacia oleracea).

Non-selective use of pesticide to increase productivity leaves residues on crops. These pesticides after consumption have a detrimental effect on human health and their intake can lead to various diseases such as kidney damage, neurological disorders, cardiovascular diseases, circulatory and reproductive problems. The recent study was designed to assess the effects of household processing treatments such as acidic solutions (acidic acid and citric acid), alkaline solutions (sodium chloride and sodium carbonate) and biological solutions (radish, ginger, garlic, and lemon extracts) were evaluated for their efficiency for removal of pesticides in spinach by gas chromatography with electron capture detector (GC-ECD).

Antioxidant properties of Milk and dairy products: a comprehensive review of the current knowledge.

Milk and dairy products are integral part of human nutrition and they are considered as the carriers of higher biological value proteins, calcium, essential fatty acids, amino acids, fat, water soluble vitamins and several bioactive compounds that are highly significant for several biochemical and physiological functions. In recent years, foods containing natural antioxidants are becoming popular all over the world as antioxidants can neutralize and scavenge the free radicals and their harmful effects, which are continuously produced in the biological body. Uncontrolled free radicals activity can lead to oxidative stresses, which have been implicated in breakdown of vital biochemical compounds such as lipids, protein, DNA which may lead to diabetes, accelerated ageing, carcinogenesis and cardiovascular diseases.

Oxidative stability and Sensoric acceptability of functional fish meat product supplemented with plantbased polyphenolic optimal extracts.

Background: Fish meat and its products are usually accepted as good source of biological high value food components and especially for polyunsaturated fatty acids. The quality of fish meat products is considered to be decreased by the lipid peroxidation which leads to reduction in nutritional quality, financial loss and severe health problems. Many tactics are present to reserve their quality and safety.

Recombinant l-glutaminase obtained from DSM-465: characterization and elucidation of conserved structural domains.

Glutaminase (GLS) is an enzyme essential for amino acid metabolism; in particular, it acts as a catalyst in glutaminolysis, a reaction exploited by the malignant cells to meet the nutrient requirements for their accelerated growth and proliferation. regulating the initial reaction of the glutaminolysis pathway, glutaminase offers an intriguing target for the development of anticancer drugs. In the present study, we produced a recombinant glutaminase from DSM-465 in .

Influence of milling pH and storage on quality characteristics, mineral and fatty acid profile of buffalo Mozzarella cheese.

Background: Currently, cheese fat is a major component of human diet due to change in eating habits. It contains a number of health destroying as well as health promoting fatty acids. Bovine milk cheese fatty acid composition is regulating by many factors.

Comparative analysis of oil composition and antibacterial activity of aerial parts of (Roxb.).

Volatile oil composition of leaves and fruits of (Roxb.) was reported for the first time. Oils were extracted by microwave assisted hydrodistillation where yield of both oils were found to be 0.

Salicylic acid-enhanced biosynthesis of pharmacologically important lignans and neo lignans in cell suspension culture of L.

L. (flax) is a perennial herb with magnitude of medicinal and commercial applications. In the present study, we investigated the effects of salicylic acid (SA) on biosynthesis of lignans (secoisolariciresinol diglucoside (SDG) and lariciresinol diglucoside (LDG)) and neolignans (dehydrodiconiferyl alcohol glucoside (DCG) and guaiacylglycerol-β-coniferyl alcohol ether glucoside (GGCG)) in cell cultures of flax.

Prevalence of molecular markers of sulfadoxine-pyrimethamine and artemisinin resistance in Plasmodium falciparum from Pakistan.

Background: In Pakistan, artesunate (AS) in combination with sulfadoxine-pyrimethamine (SP) is the recommended treatment for uncomplicated Plasmodium falciparum malaria. Monitoring molecular markers of anti-malarial drug resistance is crucial for early detection and containment of parasite resistance to treatment. Currently, no data are available on molecular markers of artemisinin resistance (K13 mutations) in P.

Potential role of root membrane phosphatidic acid in superior agronomic performance of silage-corn cultivated in cool climate cropping systems.

The literature is replete with information describing the composition of the root lipidome in several plant species grown under various environmental conditions. However, it is unknown to what extent the root membrane lipidome vary between silage-corn genotypes, and how such variation could influence agronomic performances during field cultivation in cool climate. To address this issue, the root membrane lipidome and agronomic performance were assessed for five silage-corn genotypes (Fusion-RR, Yukon-R, A4177G3-RIB, DKC23-17RIB, DKC26-28RIB) cultivated under cool climatic conditions.