Transcranial Doppler and brain MRI in children with sickle cell disease and high hemoglobin F levels.

Background/objective: While overt stroke and silent brain infarcts (SBI) are uncommon among Kuwaiti patients with sickle cell disease (SCD), there have been no previous transcranial Doppler (TCD) studies in this population. The main objective of this study is to determine TCD velocities in a group of Kuwaiti children with SCD and correlate same with brain magnetic resonance imaging (MRI) and angiography (MRA) findings.

Materials And Methods: Forty-three steady-state, pediatric patients with SCD aged 10.