Publications by authors named "Nada Kassara"
Cell Genom
September 2024
Article Synopsis
- Genetic variants in the ABCA7 gene are linked to a higher risk of Alzheimer's disease (AD), but the exact function of ABCA7 in AD development remains uncertain.*
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- Researchers created a zebrafish model lacking the abca7 gene, revealing that ABCA7 is essential for the expression of neuropeptide Y (NPY) and other neurotrophic factors vital for brain health.*
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- Findings suggest that decreased NPY due to impaired ABCA7 function contributes to synaptic issues and a higher risk of AD, with clinical data showing a correlation between NPY levels and disease progression.*
Article Synopsis
- Alzheimer's disease (AD) is a complicated condition linked to cognitive decline and memory loss, with genetic variations playing a significant role in its development, although the exact mechanisms are still unclear.
- Researchers developed a knockout zebrafish model of an established AD-risk gene using CRISPR/Cas9, which exhibited decreased astroglial growth, synaptic density, and microglial levels when exposed to amyloid beta 42 (Aβ42).
- Findings from single-cell transcriptomics indicated that neuropeptide Y (NPY) signaling is crucial for neuronal and glial interaction, while clinical data in humans showed a correlation between reduced gene expression and advanced AD stages, along with genetic variations linked to the disease.
