Zoledronic acid is an intravenous bisphosphonate that treats bone disorders by reducing bone resorption and increasing bone mineral density, helping prevent fractures.
The FDA approves it for osteoporosis in both postmenopausal women and men, generally showing good tolerability with mild side effects being musculoskeletal or gastrointestinal.
A unique case is presented where a 64-year-old female had a delayed hypersensitivity reaction to a hyaluronic acid dermal filler after receiving zoledronic acid, highlighting a previously unreported interaction.
Cutaneous polyarteritis nodosa (cPAN) is a rare form of vasculitis that affects small and medium-sized arteries in the skin, primarily causing ulceronecrotic lesions.
Diagnosis is confirmed through a skin biopsy, showing a specific type of inflammation called leukocytoclastic vasculitis.
A case study of a 14-year-old girl highlights the need for proper diagnosis and treatment, where she improved after receiving pentoxifylline and topical clobetasol propionate.