Publications by authors named "Nada Ismaiel"
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View Article and Find Full Text PDFLung-protective mechanical ventilation is known to attenuate ventilator-associated lung injury (VALI), but often at the expense of hypoventilation and hypercapnia. It remains unclear whether the main mechanism by which VALI is attenuated is a product of limiting mechanical forces to the lung during ventilation, or a direct biological effect of hypercapnia. Acute lung injury (ALI) was induced in 60 anesthetized rats by the instillation of 1.
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- An ongoing debate questions whether partial ventilatory support is harmful or helpful for patients with acute respiratory distress syndrome (ARDS), particularly in regards to ventilator-associated lung injury (VALI).
- In an experiment using rats with acute lung injury, researchers tested various levels of pressure support during ventilation, measuring changes in respiratory mechanics and lung injury.
- Findings showed that while lung injury was significant across all groups, increasing respiratory effort due to reduced pressure support did not lead to worse VALI, indicating that higher respiratory effort might not worsen lung damage in this context.
Using remifentanil in mechanically ventilated rats to provide continuous analgosedation.
J Am Assoc Lab Anim Sci
January 2012
Remifentanil is a potent synthetic opioid with sedative effects. Intravenous remifentanil provides deep sedation and analgesia in laboratory animals during experimental procedures. We hypothesized that remifentanil would provide effective analgosedation during assisted mechanical ventilation without affecting respiratory mechanics in rats.
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