Publications by authors named "Nada Ahmed Sayed"
Capturing the antimicrobial profile of Paeonia officinalis, Jasminum officinale and Rosa damascene against methicillin resistant Staphylococcus aureus with metabolomics analysis and network pharmacology.
Nourhan Hisham Shady Fatma Alzahraa Mokhtar Basma Khalaf Mahmoud Ramadan Yahia Ayman M Ibrahim Nada Ahmed Sayed
Sci Rep
June 2024
Article Synopsis
- - The study tested the antibacterial effects of root extracts from Jasminum officinale, Rosa damascena, and Paeonia officinalis against MRSA, finding that P. officinalis had significant efficacy with a minimum inhibitory concentration (MIC) of 0.4673 µg/ml, while the other two showed minimal activity.
- - Chemical profiling of P. officinalis revealed 20 different metabolites, primarily terpenes, and network pharmacology was utilized to map these metabolites' targets related to MRSA infections, using various online databases and software tools.
- - The research identified 254 targets associated with MRSA, with several key genes linked to the infection and highlighted the vascular smooth muscle contraction pathway as the top