Irisin relaxes rat thoracic aorta through inhibiting signaling pathways implicating protein kinase C.

Background: Irisin, a newly identified exercise-derived myokine, has been found involved in a peripheral vasodilator effect. However, little is known regarding the potential vascular activity of irisin, and the mechanisms underlying its effects on vascular smooth muscle have not been fully elucidated. This study was aimed to investigate the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and the hypothesis that protein kinase C (PKC) may have a role in these effects.

Potassium Channels Contributes to Apelin-induced Vasodilation in Rat Thoracic Aorta.

Background: Apelin is a newly discovered peptide hormone and originally discovered endogenous apelin receptor ligand.

Objective: In this study, we aimed to investigate the possible roles of potassium channel subtypes in the vasorelaxant effect mechanisms of apelin.

Methods: The vascular rings obtained from the thoracic aortas of the male Wistar Albino rats were placed into the isolated tissue bath system.

Vascular Functional Effect Mechanisms of Elabela in Rat Thoracic Aorta.

Background: Elabela is a recently discovered peptide hormone. The present study aims to investigate the vasorelaxant effect mechanisms of elabela in the rat thoracic aorta.

Methods: The vascular rings obtained from the thoracic aortas of the male Wistar albino rats were placed in the isolated tissue bath system.

The role of potassium channels on vasorelaxant effects of elabela in rat thoracic aorta.

Background: This study aims to investigate the roles of potassium channel subtypes in the vasorelaxant effect mechanism of elabela, which is a recently discovered endogenous apelin receptor ligand.

Methods: The vascular rings (4-mm) obtained from the thoracic aortas of 20 male Wistar Albino rats were placed into the isolated tissue bath system. The resting tension was set to 1 g.

Irisin relaxes rat thoracic aorta: MEK1/2 signaling pathway, K channels, SK channels, and BK channels are involved in irisin-induced vasodilation.

This study investigated the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and the hypothesis that mitogen-activated protein kinase kinase (MEK1/2) signaling pathway, voltage-gated potassium (K) channels, small-conductance calcium-activated potassium (SK) channels, and large-conductance calcium-activated potassium (BK) channels may have roles in these effects. Isometric contraction-relaxation responses of isolated thoracic aorta rings were measured with an organ bath model. The steady contraction was induced with 10 M phenylephrine (PHE), and then the concentration-dependent responses of irisin (10-10 M) were examined in endothelium-intact and -denuded rat thoracic aortas.

Physiological role of K channels in irisin-induced vasodilation in rat thoracic aorta.

Irisin, an exercise-induced myokine, has been shown to have a peripheral vasodilator effect. However, little is known about the mechanisms underlying its effects. In this study, it was aimed to investigate the vasoactive effects of irisin on rat thoracic aorta, and the hypothesis that voltage-gated potassium (K) channels, ATP-sensitive potassium (K) channels, small-conductance calcium-activated potassium (SK) channels, large-conductance calcium-activated potassium (BK) channels, intermediate-conductance calcium-activated potassium (IK) channels, inward rectifier potassium (K) channels, and two-pore domain potassium (K) channels may have roles in these effects.

[Pyr1]apelin-13 relaxes the rat thoracic aorta via APJ, NO, AMPK, and potassium channels.

In this study, the effect and effect mechanisms of [Pyr1]apelin-13, the dominant apelin isoform in the human cardiovascular tissues and human plasma, on vascular contractility were investigated. The vascular rings obtained from the thoracic aortas of the male Wistar Albino rats were placed in the isolated tissue bath system. After the equilibration period, [Pyr1]apelin-13 (10-9 to 10-6 M) was applied cumulatively to the aortic rings pre-contracted with phenylephrine in the plateau phase.