Publications by authors named "Nacho Romero"
Article Synopsis
- Tumour necrosis factor (TNF) signaling involves two receptors, TNFR1 and TNFR2, which help balance immune responses in the central nervous system and are relevant in autoimmune diseases like multiple sclerosis.
- Researchers used specially designed mice to test the effects of a drug called ATROSAB that targets TNFR1, finding that it significantly reduced disease severity and immune cell presence in the central nervous system after disease onset.
- The study suggests that anti-TNFR1 therapy could effectively manage autoimmune diseases by limiting immune cell infiltration without changing the overall immune system's structure or function.
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
View Article and Find Full Text PDFArticle Synopsis
- Central nervous system tuberculosis (CNS TB) leads to high mortality and morbidity due to severe inflammation and causes damage to the blood-brain barrier (BBB), which normally protects the brain.
- Mycobacterium tuberculosis (Mtb) breaks down type IV collagen and reduces tight junction protein (TJP) expression, increasing BBB permeability and enabling leukocyte migration, with this damage driven by Mtb-induced secretion of matrix metalloproteinase (MMP)-9.
- Investigating the role of the hedgehog pathway, the study finds that Mtb downregulates this pathway and decreases Scube2, which in turn inhibits Sonic hedgehog release to endothelial cells; therapies targeting MMP-9 and the hedgehog pathway show potential