The effect of the properties of cell nucleus and underlying substrate on the response of finite element models of astrocytes undergoing mechanical stimulations.

Astrocyte cells play a critical role in the mechanical behaviour of the brain tissue; hence understanding the properties of Astrocytes is a big step toward understanding brain diseases and abnormalities. Conventionally, atomic force microscopy (AFM) has been used as one of the most powerful tools to characterize the mechanical properties of cells. However, due to the complexities of experimental work and the complex behaviour of living cells, the finite element method (FEM) is commonly used to estimate the cells' response to mechanical stimulations.

Three-dimensional printing of polycaprolactone/hydroxyapatite bone tissue engineering scaffolds mechanical properties and biological behavior.

Controlled pore size and desirable internal architecture of bone scaffolds play a significant role in bone regeneration efficiency. In addition to choosing appropriate materials, the manufacturing method is another significant factor in fabricating the ideal scaffold. In this study, scaffolds were designed and fabricated by the fused filament fabrication (FFF) technique.

Mechanical guidelines on the properties of human healthy arteries in the design and fabrication of vascular grafts: experimental tests and quasi-linear viscoelastic model.

Purpose: Knowledge of mechanical behavior of healthy human arteries as the guidelines to target properties of vascular grafts deserves special attention. There is a lack of mathematical model to characterize mechanical behavior of biomaterial while many mathematical models to reflect mechanics of human arteries have been proposed. The objective of this paper was set to measure mechanical properties of healthy human arteries including Common Carotid Artery (CCA), Abdominal Aorta Artery (AAA), Subclavian Artery (SA), Common Iliac Artery (CIA) and Right and Left Iliac Artery (RIA and LIA) and compare them to those of commercial ePTFE and Dacron®.

Investigating the effect of different transducer stiffness values on the contactin complex detachment by steered molecular dynamics.

This study investigated the adhesion behavior of Contactin4 (CNTN4), a member of Immunoglobulin Super Family (Ig-SF) of cell adhesion molecules. Contactin4 plays a crucial role in the formation, maintenance, and plasticity of neuronal networks. Contactin in its complex configuration with protein tyrosine phosphatase gamma (PTPRG) was selected for simulation.

Evaluation of fibrin-gelatin hydrogel as biopaper for application in skin bioprinting: An in-vitro study.

Background: Recent advances in tissue engineering have led to the development of the concept of bioprinting as an interesting alternative to traditional tissue engineering approaches. Biopaper, a biomimetic hydrogel, is an essential component of the bioprinting process.

Objective: The aim of this work was to synthesize a biopaper made of fibrin-gelatin hybrid hydrogel for application in skin bioprinting.

A novel method for blood-typing using nitrocellulose.

Blood wicking in its steady-state form, i.e. the uniform distribution of blood cells in plasma, is completely different from that in its coagulated form on a porous surface like paper.

Design and finite element analysis of a novel smart clamper for aortic cross-clamping in minimally invasive surgery.

Aortic cross-clamping is a critical action during heart surgeries which may cause some injuries to the wall of the artery. These injuries may have both short-term and long-term adverse effects on the artery function. Appropriate clampers can properly occlude the artery and decrease the extent of injury.

A tensile machine with a novel optical load cell for soft biological tissues application.

The uniaxial tensile testing machine is the most common device used to measure the mechanical properties of industrial and biological materials. The need for a low-cost uniaxial tension testing device for small research centers has always been the subject of research. To address this need, a novel uniaxial tensile testing machine was designed and fabricated to measure the mechanical properties of soft biological tissues.