Publications by authors named "Nabila Gaber Ali Hussein"
Microneedle combined with iontophoresis and electroporation for assisted transdermal delivery of goniothalamus macrophyllus for enhancement sonophotodynamic activated cancer therapy.
Samir Ali Abd El-Kaream Nabila Gaber Ali Hussein Sohier Mahmoud El-Kholey Ahmed Mohammed Abd Elmoez Ibrahim Elhelbawy
Sci Rep
April 2024
Article Synopsis
- The study explored a novel method for delivering the drug Goniothalamus macrophyllus transdermally using microneedle arrays in combination with iontophoresis (MN-IP) and electroporation (MN-EP) to treat Ehrlich ascites carcinoma in mice.
- Results indicated that the parallel arrangement of MN electrodes at 6V effectively delivers the drug to target cancer cells, enhancing the therapeutic potential of photodynamic and sonodynamic therapies.
- The treatment significantly increased antioxidant activity and apoptotic gene expression while improving liver and kidney functions, ultimately leading to a reduction in tumor growth and induced cancer cell death.