Platelet-T cell aggregates in lung cancer patients: Implications for thrombosis.

Platelet-leukocyte aggregates (PLAs) are associated with increased thrombosis risk. The influence of PLA formation is especially important for cancer patients, since thrombosis accounts for approximately 10% of cancer-associated deaths. Our objective was to characterize and quantify PLAs in whole blood samples from lung cancer patients compared to healthy volunteers with the intent to analyze PLA formation in the context of lung cancer-associated thrombosis.

Amikacin exposure and susceptibility of macrolide-resistant .

is associated with antibiotic resistance and poor treatment outcomes. We described within-patient changes in resistance to clarithromycin and amikacin. Patients with amikacin exposure and a >50-month interval between isolates were identified.