A Prospective cohort study of zoonotic cutaneous leishmaniasis in tunisia: Clinical and Immunological features and immune correlates of protection.

Background: This study aimed to define immunological markers of exposure to L. major parasites and identify correlates of protection against infection.

Methods: We analyzed a cohort of 790 individuals at risk of developing ZCL living in endemic areas with varying L.

Topical paromomycin with or without gentamicin for cutaneous leishmaniasis.

Background: There is a need for a simple and efficacious treatment for cutaneous leishmaniasis with an acceptable side-effect profile.

Methods: We conducted a randomized, vehicle-controlled phase 3 trial of topical treatments containing 15% paromomycin, with and without 0.5% gentamicin, for cutaneous leishmaniasis caused by Leishmania major in Tunisia.