Green synthesis of ZnO-TiO/RGO nanocomposites using extract: a novel approach for enhanced anticancer efficacy and biocompatibility.

The purpose of the present study is to enhance the anticancer and biocompatibility performance of TiO NPs, ZnO NPs, ZnO-TiO (NCs), and ZnO-TiO/reduced graphene oxide (RGO) NCs against two types of human cancer (HCT116) and normal (HUVCE) cells. A novel procedure for synthesizing ZnO-TiO/RGO NCs has been developed using extract. The improved physicochemical properties of the obtained samples were investigated using different techniques such as XRD, TEM, SEM, XPS, FTIR, DLS and UV-visible spectroscopy.

Efficient Zinc Vanadate Homojunction with Cadmium Nanostructures for Photocatalytic Water Splitting and Hydrogen Evolution.

Construction of a homojunction is an effective strategy for effective charge transfer to suppress charge carrier recombination in augmented photocatalysis. The present work reveals the synthesis of homojunction formation through the reinforcement of Cd nanostructures into a solid lattice of zinc vanadate (ZnVO, ZnV) using the hydrothermal method. The formation of a homojunction between cadmium vanadate (CdV, CdVO) and ZnV was confirmed by various spectroscopic and electron microscopic techniques such as Fourier-transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) associated with energy-dispersive X-ray (EDX) mapping, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and ultraviolet-visible spectrophotometry (UV-Vis).

Identification of bioactive compounds of as potential inhibitor of pyruvate kinase M2 (PKM2): Computational and virtual screening approaches.

PKM2 (Pyruvate kinase M2) is the isoform of pyruvate kinase which is known to catalyse the last step of glycolysis that is responsible for energy production. This specific isoform is known to be highly expressed in certain cancerous conditions. Considering the role of this protein in various cancer conditions, we used PKM2 as a target protein to identify the potential compounds against this target.

Exploring optical, electrochemical, thermal, and theoretical aspects of simple carbazole-derived organic dyes.

This study highlights the recent advancements in organic electronic materials and their potential for cost-effective optoelectronic devices. The investigation focuses on the molecular design, synthesis, and comprehensive analysis of two organic dyes, aiming to explore their suitability for optoelectronic applications. The dyes are strategically constructed with carbazole as the foundational structure, connecting two electron-withdrawing groups: barbituric acid () and thiobarbituric acid ().

A Structural and Investigation of Potential CDC7 Kinase Enzyme Inhibitors.

A crucial role in the regulation of DNA replication is played by the highly conserved CDC kinase. The CDC7 kinase could serve as a target for therapeutic intervention in cancer. The primary heterocyclic substance is pyrazole, and its derivatives offer great potential as treatments for cancer cell lines.

Green Synthesis of ZnO/SnO Hybrid Nanocomposite for Degradation of Cationic and Anionic Dyes under Sunlight Radiation.

The aim of this work was to biosynthesize SnO-decorated ZnO (ZT) nanocomposites (NCs) of different Sn content (10, 20, and 30 mol%), namely, ZT10, ZT20, and ZT30, using leaf aqueous extract-based phytocompounds as nanoparticle facilitating agents for application as effective photocatalyst in the removal of dyes from polluted water. The obtained ZT NCs were characterized using various techniques, including FTIR, XRD, TGA, TEM, EDS, UV-Vis, PL, and BET surface area. X-ray diffraction patterns show that rutile SnO and hexagonal ZnO coexist in the composites, and their crystallite size (D) is affected by the SnO ratio; the obtained D-values were 17.

Identification of anti-cancer organometallic compounds by inhibition of BCL-2/Bax interactions.

Apoptosis is regulated by the BCL-2 family, which includes the anti-apoptotic and pro-apoptotic proteins (Bax, Bok, Bak, etc.). These proteins often interact in dimers and act as apoptotic switches.

Fabricated Gamma-Alumina-Supported Zinc Ferrite Catalyst for Solvent-Free Aerobic Oxidation of Cyclic Ethers to Lactones.

The aim of this work was to fabricate a new heterogeneous catalyst as zinc ferrite (ZF) supported on gamma-alumina (γ-AlO) for the conversion of cyclic ethers to the corresponding, more valuable lactones, using a solvent-free method and O as an oxidant. Hence, the ZF@γ-AlO catalyst was prepared using a deposition-coprecipitation method, then characterized using TEM, SEM, EDS, TGA, FTIR, XRD, ICP, XPS, and BET surface area, and further applied for aerobic oxidation of cyclic ethers. The structural analysis indicated spherical, uniform ZF particles of 24 nm dispersed on the alumina support.

Biofabrication of Mg-doped ZnO nanostructures for hemolysis and antibacterial properties.

The aim of this work was to synthesize 0.02 and 0.06 Mg-doped ZnO nanoparticles (NPs) using the aqueous extract of Plectranthus barbatus leaf.

Seed Extract-Mediated Synthesis of Zinc Oxide Nanoparticles: Structural, Morphological, Optical, Hemolysis, and Antibacterial Studies.

Nanomaterials have unique physicochemical properties compared to their bulk counterparts. Besides, biologically synthesized nanoparticles (NPs) have proven superior to other methods. This work aimed to biosynthesize zinc oxide (ZnO) NPs using an aqueous extract of seed.

Quinoline- and Isoindoline-Integrated Polycyclic Compounds as Antioxidant, and Antidiabetic Agents Targeting the Dual Inhibition of α-Glycosidase and α-Amylase Enzymes.

Novel analogs of quinoline and isoindoline containing various heterocycles, such as tetrazole, triazole, pyrazole, and pyridine, were synthesized and characterized using FT-IR, NMR, and mass spectroscopy, and their antioxidant and antidiabetic activities were investigated. The previously synthesized compound was utilized in conjugation with ketone-bearing tetrazole and isoindoline-1,3-dione to synthesize Schiff's bases and . Furthermore, hydrazide was treated with aryledines to provide pyrazoles -.

Efficient light-driven hydrogen evolution and azo dye degradation over the GdVO@g-CN heterostructure.

A straightforward hydrothermal technique was used for the synthesis of a g-CN/GdVO (CN/GdV) heterostructure as an alternate material for energy and environmental applications. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) were used to characterize the synthesized g-CN (CN), GdVO (GdV), and the CN/GdV heterostructure. The characterization results revealed the distribution of GdV over CN sheets.

Activating the delivery of a model drug to lipid membrane by encapsulation of cyclodextrin: Combined experimental and molecular docking studies.

Drug delivery science is always an important topic as it studies the delivery of therapeutic payloads to the desired target cells without affecting the healthy tissues/cells, thus minimizing drug-induced toxicity. Aiming towards the targeted drug delivery, the present project deals with the delivery of a polarity-sensitive solvatochromic model drug, namely, salt of 8-anilinonaphthalene-1-sulphonic acid (ANSA) to the model bio-membrane (which mimic several aspects of the real cell membrane), more precisely at the lipid-water interface of L-α-Dipalmitoylphosphatidylcholine (DPPC) phospholipid. The drug delivery process has been activated through the binding of dye with cyclodextrin, acting as a drug transporter.

Multifunctional Zn(II) Coordination Polymer as Highly Selective Fluorescent Sensor and Adsorbent for Dyes.

A new Zn(II)-based coordination polymer () comprising the Schiff base ligand obtained by the condensation of 5-aminosalicylic acid and salicylaldehyde has been synthesized. This newly synthesized compound has been characterized by analytical and spectroscopic methods, and finally, by single-crystal X-ray diffraction technique in this study. The X-ray analysis reveals a distorted tetrahedral environment around the central Zn(II) center.

Antiproliferative Mechanisms of a Polyphenolic Combination of Kaempferol and Fisetin in Triple-Negative Breast Cancer Cells.

Herein, we investigate the combinatorial therapeutic effects of naturally occurring flavonoids kaempferol (K) and fisetin (F) on triple-negative breast cancer (TNBC: MDA-MB-231 cell line). Dose-dependent MTT assay results show that K and F exhibited cytotoxicity in MDA-MB-231 cells at 62 and 75 μM (IC), respectively, after 24 h. However, combined K + F led to 40% and more than 50% TNBC cell death observed at 10 and 20 μM, respectively, which revealed the synergistic association of both.

Influence of Eugenol and Its Novel Methacrylated Derivative on the Polymerization Degree of Resin-Based Composites.

The aim of this work was to assess the limiting rate of eugenol (Eg) and eugenyl-glycidyl methacrylate (EgGMA) at which the ideal degree of conversion (DC) of resin composites is achieved. For this, two series of experimental composites, containing, besides reinforcing silica and a photo-initiator system, either EgGMA or Eg molecules at 0-6.8 wt% per resin matrix, principally consisting of urethane dimethacrylate (50 wt% per composite), were prepared and denoted as UGx and UEx, where x refers to the EgGMA or Eg wt% in the composite, respectively.

Quantum Computational, Spectroscopic (FT-IR, FT-Raman, NMR, and UV-Vis) Hirshfeld Surface and Molecular Docking-Dynamics Studies on 5-Hydroxymethyluracil (Monomer and Trimer).

For many decades, uracil has been an antineoplastic agent used in combination with tegafur to treat various human cancers, including breast, prostate, and liver cancer. Therefore, it is necessary to explore the molecular features of uracil and its derivatives. Herein, the molecule's 5-hydroxymethyluracil has been thoroughly characterized by NMR, UV-Vis, and FT-IR spectroscopy by means of experimental and theoretical analysis.

Ternary Copper Tungsten Sulfide (CuWS) Nanoparticles Obtained through a Solvothermal Approach: A Bi-Functional Electrocatalyst for the Hydrogen Evolution Reaction (HER) and Oxygen Evolution Reaction (OER).

In this work, CuWS nanoparticles have been synthesized via a solvothermal decomposition approach using a heterobimetallic single source precursor, WCuS(PPh). The single source precursor, WCuS(PPh), has been characterized using multinuclear NMR spectroscopy, while CuWS nanoparticles have been characterized by powder X-ray diffraction (PXRD) for which Rietveld refinement has been performed to authenticate the lattice structure of the decomposed product, CuWS. Furthermore, FESEM and EDAX analyses have been performed to assess the morphology and composition of CuWS.

Activated Carbon/ZnFeO Nanocomposite Adsorbent for Efficient Removal of Crystal Violet Cationic Dye from Aqueous Solutions.

The aim of this study was to investigate the potential advantage of ZnFeO-incorporated activated carbon (ZFAC), fabricated via a simple wet homogenization, on the removal of cationic dye crystal violet (CV) from its aqueous solutions. The as-prepared ZFAC nanocomposite was characterized using Fourier transform infrared (FTIR), X-ray diffraction (XRD), nitrogen adsorption, scanning electron microscope (SEM), thermogravimetric analysis (TGA), and ultraviolet-visible (UV-Vis). Batch adsorption operating conditions such as the pH (3-11), CV concentration (25-200 ppm), ZFAC dose (10-50 mg), temperature (23-45 °C), and contact time were evaluated.

Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs.

Alteration in the pattern of epigenetic marking leads to cancer, neurological disorders, inflammatory problems These changes are due to aberration in histone modification enzymes that function as readers, writers and erasers. Bromodomains (BDs) and BET proteins that recognize acetylation of chromatin regulate gene expression. To block the function of any of these BrDs and/or BET protein can be a controlling agent in disorders such as cancer.

A fluorescent Cu(ii) complex as a dual functional sensor for selective and sensitive detection of acetone and Cd(ii) pollutants.

In this study, Cu perchlorate complexes of 3,5-dimetylpyrazole(dmpy), namely [Cu(dmpy)(HO)](HO)(ClO) (1), were prepared and characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), infrared (IR) spectroscopy, elemental analysis, mass spectrometry, and ultraviolet visible (UV-Vis) spectroscopy. It was determined that Cu coordinated to the nitrogen atoms of three dmpy molecules as well as to the oxygen atoms of two HO molecules in a square pyramidal geometry. To balance the charge, two uncoordinated perchlorate anions and one HO molecule were also present in the lattice.