Serum carotenoids and alpha-tocopherol and risk of nonmelanoma skin cancer.

Background: Carotenoids and tocopherols have been hypothesized to protect against cancer.

Methods: We prospectively evaluated associations of several carotenoids and alpha-tocopherol with risk of nonmelanoma skin cancer using serum collected at baseline from 302 subjects in the Isotretinoin-Basal Cell Carcinoma Prevention Trial. All subjects had at least two BCCs in the 5 years prior to randomization.