Quantum Simulation of Partial Differential Equations via Schrödingerization.

We present a novel new way-called Schrödingerization-to simulate general (quantum and nonquantum) systems of linear ordinary and partial differential equations (PDEs) via quantum simulation. We introduce a new transform, referred to as the warped phase transformation, where any linear-including nonautonamous-system of ordinary or partial differential equation can be recast into a system of Schrödinger's equations, in real time, in a straightforward way. This approach is not only applicable to PDEs for classical problems but is also useful for quantum problems, including the preparation of quantum ground states and Gibbs thermal states, the simulation of quantum states in random media in the semiclassical limit, simulation of Schrödinger's equation in a bounded domain with artificial boundary conditions, and other non-Hermitian physics.

Preclinical development of lentiviral vector gene therapy for Diamond-Blackfan anemia syndrome.

Diamond-Blackfan anemia syndrome (DBAS) is an inherited bone marrow failure disorder caused by haploinsufficiency of ribosomal protein genes, most commonly RPS19. Limited access to patient hematopoietic stem/progenitor cells (HSPCs) is a major roadblock to developing novel therapies for DBAS. We developed a novel self-inactivating third-generation RPS19-encoding lentiviral vector (LV), termed "SJEFS-S19", for DBAS gene therapy.

Prosocial behavior associated with trait mindfulness, psychological capital and moral identity among medical students: a moderated mediation model.

Purpose: As future doctors, medical students' prosocial behaviors may affect the relationship between doctors and patients. This study aims to explore the effects of trait mindfulness on prosocial behaviors, as well as the mediating role of psychological capital and the moderating role of moral identity among medical students.

Methods: A cross-sectional survey was conducted between July and October 2023 across four medical colleges in China, using cluster random sampling.

Lognormal mode dissociation method based on intrinsic characteristics of aerosol size distribution.

Aerosols significantly affect the transmission of optical signals in the atmosphere, necessitating accurate atmospheric models for the performance evaluation of electro-optic devices. Aerosol size distribution is a critical parameter in these models, and the lognormal function is commonly used to mathematically represent it. This study aims to handle the lack of a solid criterion for determining the number of lognormal modes and introduces an improved scheme that leverages the characteristics of the second derivative (SD) of the Gaussian curve to identify the mode amount and to initialize mode parameters for fitting.

The relationship between loneliness and psychological distress among Chinese college students: the mediating role of mobile phone addiction and the moderating role of core self-evaluation.

Previous studies showed that loneliness and psychological distress are related. However, the potential mechanisms involved in this relationship are unknown. This study examined the mediating effect of mobile phone addiction and the moderating effect of core self-evaluation on the relationship between mobile phone addiction and psychological distress.

Transcriptomic Insights into the Atrial Fibrillation Susceptibility Locus near the and Genes.

Genome-wide association studies have identified a locus on chromosome 10q22, where many co-inherited single nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF). This study seeks to identify the impact of this locus on gene expression at the transcript isoform level in human left atria and to gain insight into potential causal variants. Bulk RNA sequencing was analyzed to identify myozenin 1 () and synaptopodin 2-like () transcript isoforms and the association of common SNPs in this region with transcript isoform expression levels.

Effects of Polyethylene Terephthalate Microplastics on Anaerobic Mono-Digestion and Co-Digestion of Fecal Sludge from Septic Tank.

Anaerobic digestion (AD) is one of the most significant processes for treating fecal sludge. However, a substantial amount of microplastics (MPs) have been identified in septic tanks, and it remains unclear whether they impact the resource treatment of feces. To investigate this, polyethylene terephthalate (PET) was used as an indicator of MPs to study their effect on the anaerobic digestion of fecal sludge (FS).

Temperature-Dependent Supramolecular Isomeric Co-CPs for Luminescence Recognition and Catalytic Oxidation.

Two Co-based supramolecular isomers were synthesized from a fluorinated carboxylic acid ligand under hydrothermal conditions at varying temperatures. Both exhibited similar one-dimensional chain structures while different bending connections of the aromatic rings led to different supramolecular structures, namely CoCP-1 and CoCP-2, respectively. The structural differences of two isomers resulted in discrepant performance with regards to luminescence sensing and catalysis.

Two Thiophene-Functionalized Co-MOFs as Green Heterogeneous Catalysts for the Biginelli Reaction.

Two Co(II) metal-organic frameworks (Co-MOFs), namely, [Co(DMTDC)(bimb)] () and {[Co(DPTDC)(bimb)(HO)]·2DMF} () (HDMTDC = 3,4-dimethylthieno[2,3-]thiophene-2,5-dicarboxylic acid, HDPTDC = 3,4-diphenylthieno[2,3-]thiophene-2,5-dicarboxylic acid, bimb = 1,4-bis((1-imidazol-1-yl)methyl)benzene), were obtained by the reaction of flexible N-containing ligand bimb and two structurally related thiophene-containing ligands HDMTDC and HDPTDC, respectively. These Co-MOFs displayed a 3D framework and porous structure, respectively. and the activated sample could act as green heterogeneous catalysts for the one-pot multicomponent Biginelli reaction, specifically the dehydration condensation process involving aldehydes, acetoacetates, and urea to yield dihydropyrimidin-2(1)-ones.

Common Genetic Variant Associated With Atrial Fibrillation Lowers Expression of Nesprin-2α1 With Downstream Effects on Nuclear and Electrophysiological Traits.

Background: Atrial fibrillation GWAS (genome-wide association studies) identified significant associations for rs1152591 and linked variants in the gene encoding Nesprin-2, which connects the nuclear membrane with the cytoskeleton.

Methods: Reporter gene vector transfection and CRISPR-Cas9 editing were used to identify the causal variant regulating the expression of . After knockdown or overexpression in human stem cell-derived cardiomyocytes, nuclear phenotypes were assessed by imaging and atomic force microscopy.

A paradigm shift in oncology imaging: a prospective cross-sectional study to assess low-dose deep learning image reconstruction versus standard-dose iterative reconstruction for comprehensive lesion detection in dual-energy computed tomography.

Background: Low-kiloelectron volt (keV) virtual monochromatic images (VMIs) from low-dose (LD) dual-energy computed tomography (DECT) can enhance lesion contrast but suffer from high image noise. Recently, a deep learning image reconstruction (DLIR) algorithm has been developed and shown significant potential in suppressing image noise and improving image quality. To date, the capacity of LD low-keV thoracic-abdominal-pelvic DECT with DLIR to detect various types of tumor lesions have not been assessed.

Regulation of PPy Growth States by Employing Porous Organic Polymers to Obtain Excellent Microwave Absorption Performance.

Regulating the different growth states of polypyrrole (PPy) is a key strategy for obtaining PPy composites with high electromagnetic wave (EMW) absorption properties. This work finds that the growth states of PPy is regulated by controlling the amount of pyrrole added during the preparation of composites, so as to regulate the development of conductive networks to obtain excellent EMW absorption performance. The POP/PPy-200 composite achieves an effective absorption bandwidth (EAB) of 6.

Cardioneuroablation can be an effective strategy to treat glossopharyngeal neuralgia-related sinus bradycardia and pauses.

Introduction: Cardioneuroablation (CNA) has proven effectiveness in addressing hypervagotonia symptoms, such as neurocardiogenic syncope.

Methods And Results: In this case, we present the first-time application of CNA in a case of vago-glossopharyngeal neuralgia (VGPN). A 59-year-old female with near-syncope, sinus bradycardia, and sinus pauses triggered by recurrent right-sided neck pain was diagnosed with VGPN.

Factors influencing accelerated aging in patients with type 2 diabetes mellitus and coronary heart disease.

Objective: To investigate the factors influencing accelerated aging in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD).

Methods: A total of 216 patients diagnosed with T2DM and CHD between August 2019 and August 2023 at Xuzhou Central Hospital were selected. Patients were divided into an aging group and a non-aging group, based on the positive or negative values of phenotypic age acceleration (PhenoAgeAccel).

Short-term efficacy of microwave ablation in the treatment of liver cancer and its effect on immune function.

Background: Hepatectomy is the first choice for treating liver cancer. However, inflammatory factors, released in response to pain stimulation, may suppress perioperative immune function and affect the prognosis of patients undergoing hepatectomies.

Aim: To determine the short-term efficacy of microwave ablation in the treatment of liver cancer and its effect on immune function.

A robust triphenylamine-based monolithic polymer network for selective sieving of CO and PM from flue gas.

The increasingly urgent issue of climate change is driving the development of carbon dioxide (CO) capture and separation technologies in flue gas after combustion. The monolithic adsorbent stands out in practical adsorption applications for its simplified powder compaction process while maintaining the inherent balance between energy consumption for regeneration and selectivity for adsorption. However, optimizing the adsorption capacity and selectivity of CO separation materials remains a significant challenge.

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase.

DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no base editor for direct thymine (T) editing currently. Here we develop two deaminase-free glycosylase-based base editors for direct T editing (gTBE) and C editing (gCBE) by fusing Cas9 nickase (nCas9) with engineered human uracil DNA glycosylase (UNG) variants. By several rounds of structure-informed rational mutagenesis on UNG in cultured human cells, we obtain gTBE and gCBE with high activity of T-to-S (i.

Polygenic Score for Conscientiousness Is a Protective Factor for Reversion from Mild Cognitive Impairment to Normal Cognition.

Spontaneous reversion from mild cognitive impairment (MCI) to normal cognition (NC) is little known. Based on the data of the Genetics of Personality Consortium and MCI participants from Alzheimer's Disease Neuroimaging Initiative, the authors investigate the effect of polygenic scores (PGS) for personality traits on the reversion of MCI to NC and its underlying neurobiology. PGS analysis reveals that PGS for conscientiousness (PGS-C) is a protective factor that supports the reversion from MCI to NC.