Bitter acids (BA) are main component of Humulus lupulus L. (hops). They are known for beer brewing and have various biological and pharmacological properties, especially the bone-protective effect confirmed by our previous in vivo study.
View Article and Find Full Text PDFEthnopharmacological Relevance: Fructus Ligustri Lucidi (FLL), the fruit of Ligustrum lucidum Ait., is a traditional Chinese medicine that has been used for tonifying the kidney and liver for decades.
Aim Of The Study: This study aimed to explore and identify polysaccharides from FLL and elucidate its protective effect against renal fibrosis.
Hops, the dried female clusters from Humulus lupulus L., have traditionally been used as folk medicines for treating insomnia, neuralgia, and menopausal disorders. However, its pharmacological action on iron overload induced nerve damage has not been investigated.
View Article and Find Full Text PDFBackground: Our early studies performed on aged rats, ovariectomized (OVX) rats and diabetic mice, indicated the calciotropic role of Fructus Ligustri Lucidi (FLL), the fruit of Ligustrum lucidum Ait., in mediating calcium homeostasis which was partially attributed to its stimulation on renal calcium reabsorption.
Purpose: This study aimed to explicate the underlying molecular mechanism and explore the potential bioactive ingredients in FLL.
Xanthohumol, a natural isoflavone from Humulus lupulus L., possesses biological activities. However, the biological fate of xanthohumol in vivo remains unclear.
View Article and Find Full Text PDFObjectives: Xanthohumol (XAN) is a unique component of Humulus lupulus L. and is known for its diverse biological activities. In this study, we investigated whether Xanthohumol could ameliorate memory impairment of APP/PS1 mice, and explored its potential mechanism of action.
View Article and Find Full Text PDFOxidative stress is a crucial pathogenic factor in osteoporosis. Autophagy is a cellular self-digestion process that can selectively remove damaged organelles under oxidative stress, and thus presents a potential therapeutic target against osteoporosis. Monotropein is an iridoid glycoside which can increase osteoblastic bone formation and be applied for medicinal purpose in China.
View Article and Find Full Text PDFSurgery and the local placement of an antibiotic are the predominant therapies to treat chronic osteomyelitis. Vancomycin-loaded -trimethyl chitosan nanoparticles (VCM/TMC NPs) as a potential drug delivery system have high intracellular penetration and effective intracellular antibacterial activity. This study investigated the effects of a biocompatible material, poly(trimethylene carbonate) (PTMC), to increase the sustained effectiveness of an intracellular antibiotic and its potential application in antibiotic delivery.
View Article and Find Full Text PDFObjective: To optimize and determine the artificial cultivated conditions of Phellinus igniarius by Response Surface Method.
Methods: With the index for the content of hypholomine B which was the main component of alcohol extract of Phellinus igniarius, the effect factors such as cultivated temperature, humidity, substrate types and illumination time were investigated respectively. By univariate analysis of variance, three most influential factors designed by BBD ( Box-Behnken Design) response surface optimization were selected to determine the optimal combination of them.