Publications by authors named "Na-Xin Sun"
Int J Biol Macromol
March 2019
Article Synopsis
- Grifola frondosa, a popular edible and medicinal mushroom, was found to extract a cold-water-soluble polysaccharide (cGFP) that impacts the growth and death of human liver cancer cells (HepG2).
- The study revealed that cGFP triggers apoptosis (programmed cell death) in HepG2 cells in a dose-dependent manner, mainly by halting the cell cycle in the S phase and showing distinct apoptotic characteristics under electron microscopy.
- Mechanistically, cGFP's effect involves a reduction in mitochondrial membrane potential and changes in the expression of apoptosis-related proteins, indicating it works through the mitochondrial pathway by promoting pro-apoptotic factors (Bax) and inhib
