Publications by authors named "Na-Na Yu"
Article Synopsis
- This study examines how tau pathology affects episodic memory loss in Alzheimer's disease (AD), focusing specifically on ventral hippocampal CA1 (vCA1) neurons and their response to tau accumulation.
- Using various methods including proteomic analysis and social behavior tests on mice, the research identifies significant changes in excitatory and parvalbumin neurons in vCA1 associated with AD-like conditions.
- The findings suggest that activating these neurons can improve social memory impaired by tau, and that administering ursolic acid may reduce tau accumulation and restore neuron function, highlighting potential therapeutic approaches for AD-related memory loss.
This work reports the refinement of nanoporous copper (NPC) ligaments by introducing the sodium dodecyl sulfate (SDS) surfactant in the dealloying process. The AlCu (at%) alloy precursor is chemically dealloyed in a mixed solution of NaOH and SDS surfactant, producing NPC with a hierarchical microstructure. Micron-scaled skeletons that build up higher level networks consist of geometrically similar nano-scaled bi-continuous ligament-pore networks at the lower level.
View Article and Find Full Text PDFBackground: We have reported previously the insufficient absolute number or functional defects of regulatory T cells (Tregs) in patients with rheumatoid arthritis (RA), challenging conventional unspecific immunosuppressive therapy. Sirolimus, a mTOR inhibitor, is reported to allow growth of functional Tregs; here, we investigated the efficacy of low-dose sirolimus combined with conventional immunosuppressants (sirolimus immunoregulation therapy) for RA treatment with lower side effects and better tolerance.
Methods: In this nonblinded and parallel-group trial, we randomly assigned 62 patients to receive conventional glucocorticoids and immunosuppressants with or without sirolimus at a dosage of 0.
Objectives: To investigate changes in the hepatic apparent diffusion coefficient (ADC) in patients undergoing chemotherapy.
Methods: We enrolled 54 patients (25 women; mean age 57.0±13.