Regulation strategies of microplastics with different particle sizes on cadmium migration processes and toxicity in soil-pakchoi system.

It is still unclear whether there are differences in the effects of microplastics with different particle sizes on the environmental behavior of cadmium (Cd) in the soil-crop system. By introducing the polystyrene microplastics (PS-MPs) with 0.2, 2, and 20 μm, this study explored the regulation strategies of different-sized MPs on the migration and toxicity of Cd in the soil-pakchoi system.

OAB-14 alleviates mitochondrial impairment through the SIRT3-dependent mechanism in APP/PS1 transgenic mice and N2a/APP cells.

Alzheimer's disease (AD) is a progressive degenerative disease that affects a growing number of elderly individuals worldwide. OAB-14, a novel chemical compound developed by our research group, has been approved by the China Food and Drug Administration (FDA) for clinical trials in patients with AD (approval no. YD-OAB-220210).

A homozygous loss-of-function mutation in CEP250 is associated with acephalic spermatozoa syndrome in humans.

Background: The presence of predominantly headless sperm in semen is a hallmark of acephalic spermatozoa syndrome, which is primarily caused by gene mutations in humans.

Purpose: To identify genetic causes for acephalic spermatozoa syndrome.

Methods: Polymerase chain reaction and Sanger sequencing were performed to define mutations in SUN5 and PMFBP1.

Association between stroke subtypes and outcomes of endovascular therapy: a post-hoc analysis of the ANGEL-ASPECT Trial.

Objectives: Our study aims to examine the value of endovascular therapy (EVT) and its comparison to medical management (MM) in ischaemic stroke patients accompanied by large artery atherosclerosis (LAA) and non-LAA METHODS: modified Rankin scale score (mRS) was evaluated at 90 days post the stroke attack and was considered as the primary outcome. Other outcomes measured in this study included score changes of 0-2 and 0-3 on the mRS. The occurrence of symptomatic intracranial haemorrhage at 24 hours after EVT was also measured as a safety endpoint.

One-step hydrothermal synthesis of CQDs/TiO/NH-MIL-125 for efficient photocatalytic production of HO under visible light.

NH-MIL-125 and its derivatives are receiving more attention in various aspects of photocatalytic reactions, especially in the photocatalytic hydrogen peroxide (HO) production from water (HO) and oxygen (O), which is a promising and sustainable strategy. However, the generation of HO from NH-MIL-125 is far from satisfactory due to rapid photo-generated carriers recombination and poor surface electron transfer. In the work, the composite photocatalyst CQDs/TiO/NH-MIL-125 (C/T/NM) was designed for the first time by one-step hydrothermal method.

Optimal control of vaccination for an epidemic model with standard incidence rate.

A critical challenge for diseases spread is the development of effective prevention and control measures while minimizing costs, representing the foremost priority. Unfortunately, research in this crucial area remains inadequately explored. Consequently, this paper addresses the issue by leveraging an SI reaction-diffusion epidemic model incorporating a logistic birth rate and standard incidence rate.

Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa , Male Zebrafish , and GC-1 Cells .

Background: Legacy brominated flame retardants have been recognized as risky factors leading to declined sperm quality. The widespread utilization of decabromodiphenyl ethane (DBDPE) as a replacement for decabromodiphenyl ether has given rise to considerable concern over its potential risks to reproductive health.

Objectives: The objectives were to quickly determine whether DBDPE affects sperm quality upon exposure, to reveal the reproductive outcomes and underlying molecular mechanisms using an zebrafish model exposed to DBDPE, and to validate the potential impact on DNA damage and energy metabolism balance .

Combined effects and potential mechanisms of phthalate metabolites on serum sex hormones among reproductive-aged women: An integrated epidemiology and computational toxicology study.

The reproductive age is a crucial stage for women to bear offspring. However, reproductive-aged women are simultaneously exposed to various phthalates, which may pose a threat to their reproductive health. This study employed generalized linear regression and weighted quantile sum (WQS) regression to explore the associations between monoesters of phthalates (MPAEs) and sex hormones in 913 reproductive-aged women in the National Health and Nutrition Examination Survey.

Novel and recurrent hemizygous variants in BCORL1 cause oligoasthenoteratozoospermia by interfering transcription.

Background: Oligoasthenoteratozoospermia (OAT) is a common cause of male infertility, of which the causes remain largely unknown. Recently, BCORL1 was identified as a contributor to male infertility from non-obstructive azoospermia (NOA) to OAT.

Objectives: To identify novel and hotspot variants in BCORL1 from infertile men with OAT and reveal their outcomes of assisted reproductive treatments (ARTs).

Association between plant microbiota and cadmium uptake under the influence of microplastics with different particle sizes.

Plant microbiota are an important factor impacting plant cadmium (Cd) uptake. However, little is known about how plant microbiota affects the Cd uptake by plants under the influence of microplastics (MPs) with different particle sizes. In this study, bacterial structure and assembly in the rhizosphere and endosphere in pakchoi were analyzed by amplicon sequencing of 16S rRNA genes under the influence of different particle sizes of polystyrene microplastics (PS-MPs) combined with Cd treatments.

Phthalate monoesters accumulation in residential indoor dust and influence factors.

Phthalate monoesters (mPAEs) possess biological activity that matches or even exceeds that of their parent compounds, phthalate esters (PAEs), negatively impacting humans. Indoor dust is the main carrier of indoor pollutants. In this study, indoor dust samples were collected from 46 households in Changchun City, Jilin Province, in May 2019, and particulate and flocculent fibrous dust was used as the research target to analyze the concentration and compositional characteristics of mPAEs, primary metabolites of five significant PAEs.

Intraoperative application of low-dose dexmedetomidine or lidocaine for postoperative analgesia in pediatric patients following craniotomy: a randomized double-blind placebo-controlled trial.

Background: Postoperative pain is a common occurrence in pediatric patients following craniotomy, often leading to negative outcomes. Intravenous dexmedetomidine and lidocaine are commonly used adjuvant medicines in general anesthesia to reduce perioperative opioid consumption and relieve postoperative pain in adults. While they show promise for use in pediatrics, the evidence of their application in pediatric craniotomy patients is limited.

Enhanced immobilization of cadmium and lead in contaminated soil using calcium alginate-modified HAP biochar: Improvements in soil health and microbial diversity.

A novel adsorbent, calcium alginate-modified HAP (Hydroxyapatite)-wood ear mushroom sticks biochar (CA-HAP), was synthesized to enhance the immobilization of Cd and Pb in soil. Over 150 days, applying CA-HAP at concentrations of 0%-3% in contaminated soils from Chenzhou City in Hunan Province (CZ) and Shenyang City in Liaoning Province (SY) resulted in decreased effective concentrations of Cd and Pb. Specifically, in CZ soil, Cd and Pb decreased by 30.

Drying kinetics and energy efficiency of soot ash of smelting silicon manganese alloys under microwave heating.

When smelting silicon manganese alloy in an industrial electric furnace, it will produce smoke and dust waste gas, which can be utilized again back to the furnace and improve the utilization rate of raw materials after a particular trapping device and collection treatment. However, at higher moisture levels, they are prone to explode. Effects of various initial masses, initial moisture contents, and microwave output powers on the soot ash of smelting silicon manganese alloy were studies.

Unraveling the Impact of the PROCA1 Mutation in Male Infertility: Incorporating Whole Exome Sequencing in Teratozoospermia Patients and Analyzing Proca1 Knockout Mice.

In the world, about 15% of couples are infertile, and nearly half of all infertility was caused by men. A large number of genetic mutations are thought to affect spermatogenesis by regulating acrosome formation. Here, we identified three patients harbouring the protein interacting with cyclin A1 (PROCA1) mutation by whole exome sequencing (WES) and Sanger sequencing among patients with predominantly acrosome-deficient teratozoospermia.

Therapeutic potential of vitamin D3 in mitigating high glucose‑induced renal damage: Mechanistic insights into oxidative stress inhibition and TXNIP/NLRP3 signaling pathway blockade.

In the development of diabetic nephropathy, pathological damage such as interstitial fibrosis and cell apoptosis often occur in renal tubules. In the present study, diabetic and control group mice were randomly treated with vitamin D3 or vehicle for 6 months. In addition, human renal tubular epithelial (HK-2) cells were cultured in high-glucose medium and treated with vitamin D3 or the oxidative inhibitor NAC.