An Investigation of the Anticancer Mechanism of L. Extract Against Colorectal Cancer by Integrating a Network Pharmacological Analysis and Experimental Validation.

L. has exhibited various pharmacological effects, yet its anticancer activities against colorectal cancer (CRC) and underlying molecular mechanisms remain unclear. This study investigated the anticancer properties of an ethanol extract of L.

Ellagic Acid from and Antimalarial Activity of Korean Medicinal Plants.

This study investigates the antimalarial potential of extracts and compounds from various plants used in traditional Korean medicine, in response to the increasing resistance of to standard treatments such as chloroquine and artemisinin. The antimalarial activity screening was conducted on 151 extracts, identifying the top seven candidates, including (50% ethanol and 100% methanol extract), , (hot water and 50% ethanol extract), , and . Among these, was identified as the top priority for further analysis due to its high antimalarial activity and high yield of bioactive compounds.

. Honey Exerts Antiviral Effect Against Influenza A Virus Infection Through Mitochondrial Stress-Mediated Enhancement of Innate Immunity.

To combat influenza A virus (IAV) infection, it is vital to develop effective therapeutic strategies, including immunomodulators. In this study, we examined the antiviral effects of Hovenia dulcis Thunb. honey (HDH) against IAV using RAW 264.

Estimating the Impact of Aging on Visual Function Using Useful Field of View (UFOV) with a Focus on the Population of Gangwon-do in Korea.

Background/objectives: There is a need in Korea for research estimating the impact of aging using the Useful Field Of View (UFOV) test, which can evaluate visual function for elderly drivers.

Methods: This observational study involved young people in their twenties and thirties, later-middle-aged people in their fifties or older, and elderly people 65 or older recruited from the Gangwon-do region. UFOV testing was conducted on the participants where the participants completed a questionnaire about general and driving-related characteristics.

Formation Cycle Control for Enhanced Structural Stability of Ni-Rich LiNiCoMnO Cathodes.

Nickel-rich NCM cathode materials promise lithium-ion batteries with a high energy density. However, an increased Ni fraction in the cathode leads to complex phase transformations with electrode-electrolyte side reactions, which cause rapid capacity fading. Here, we show that an initial formation cycle at 0.

Enhancement of Osseointegration via Endogenous Electric Field by Regulating the Charge Microenvironments around Implants.

The regulation of the charged microenvironment around implants is an effective way to promote osseointegration. Although homeostasis of the charged microenvironment plays an integral role in tissues, current research is externally invasive and unsuitable for clinical applications. In this study, functional materials with different surface potential differences are prepared by changing the spatial layout of Ta and Ag on the surface of a Ti-6Al-4V alloy (TC4).

Hidden route of protein damage through oxygen-confined photooxidation.

Oxidative modifications can disrupt protein folds and functions, and are strongly associated with human aging and diseases. Conventional oxidation pathways typically involve the free diffusion of reactive oxygen species (ROS), which primarily attack the protein surface. Yet, it remains unclear whether and how internal protein folds capable of trapping oxygen (O) contribute to oxidative damage.

Epidemiological Characteristics and Outcome of Myocarditis and Pericarditis Temporally Associated With BNT162b2 COVID-19 Vaccine in Adolescents: Korean National Surveillance.

Background: This study aimed to investigate the epidemiological characteristics and outcomes of myocarditis/pericarditis after BNT162b2 vaccination in Korean adolescents.

Methods: This was a retrospective cohort analysis of adolescents aged 12-19 years old diagnosed with myocarditis/pericarditis within 42 days of BNT162b2 mRNA vaccination. All reported cases were investigated by city or government epidemiologists and the diagnostic certainty and causality was determined by the Korea Disease Control and Prevention Agency's Adverse Event Following Immunization Expert Advisory Committee according to the modified version of Brighton Collaboration Myocarditis/Pericarditis Working group's case definitions.

The Application of the NOSES System to Treat Cheek Squamous Cell Carcinoma.

Purpose: Oral squamous cell carcinoma is one of the most common types of cancer in the head and neck. Squamous cell carcinoma of the buccal mucosa is an important part of it. The traditional surgical method leads to great injury and is accompanied by unacceptable scars.

Complete genome sequence of sp. SCR221107, encoding biosynthesis of vitamin B isolated from the rumen fluid of Holstein dairy cows.

sp. SCR221107 was isolated from the rumen fluid of healthy male Holstein dairy cows from a research farm at Suncheon, Jeollanam-do, Korea. sp.

The Role of the Cytoskeletal Regulatory Protein, Mammalian Enabling Protein (Mena), in Invasion and Metastasis of HPV16-Related Oral Squamous Cell Carcinoma.

Background: The objective of this study was to investigate the effect of mammalian-enabled protein (Mena) on invasion and metastasis of HPV16-related oral squamous cell carcinoma (OSCC) and the underlying mechanism.

Materials And Methods: The Mena gene expression profile of HPV-related OSCC was analyzed from the TCGA, GEO and TIMER databases. Immunohistochemistry was performed to study Mena, and the expression of invasion and metastasis-related markers and their clinicopathological characteristics.

PPAR affects hepatic lipid homeostasis by perturbing necroptosis signals in the intestinal epithelium.

Rapid turnover of the intestinal epithelium is a critical strategy to balance the uptake of nutrients and defend against environmental insults, whereas inappropriate death promotes the spread of inflammation. PPAR is highly expressed in the small intestine and regulates the absorption of dietary lipids. However, as a key mediator of inflammation, the impact of intestinal PPAR signaling on cell death pathways is unknown.

Blockade of Voltage-Gated K Channels in Rabbit Coronary Arterial Smooth Muscle Cells by the Antipsychotic Drug Zotepine.

Zotepine is a second-generation antipsychotic that demonstrates significant efficacy in antagonizing D and 5-HT receptors. Although clinical investigations have shown that administering zotepine is associated with an increased prevalence of hyperglycemia and a heightened risk of cardiovascular disease, the side effects of zotepine on voltage-gated K (Kv) channels have not been established. Zotepine suppressed the vascular Kv channels in rabbit coronary arterial smooth muscle cells in a concentration-dependent manner, with an IC of 5.

First report of the family Attevidae (Lepidoptera, Yponomeutoidea) from Cambodia, with description of a new species.

In the present study, we report a pantropical family Attevidae of the superfamily Yponomeutoidea in Cambodia for the first time. A new species, Atteva chalco sp. nov.

NIR-Guided Coating Optimization of Omega-3 Fatty Acid Mini Soft Capsules with Pitavastatin and Ezetimibe.

Background: This study aimed to optimize the coating process of Omega-3 fatty acid (OM3-FA) mini soft capsules containing the active pharmaceutical ingredients (APIs) pitavastatin and ezetimibe using near-infrared (NIR) spectroscopy for in-process monitoring. Cardiovascular disease treatments benefit from combining OM3-FA with lipid-lowering agents, but formulating such combinations in mini soft capsules presents challenges in maintaining stability and mechanical integrity.

Methods: The coating process was developed using a pan coater and real-time NIR monitoring to ensure uniformity and quality.

A narrative exploration of psilocybin's potential in mental health.

Psilocybin, a psychoactive substance, has recently garnered attention for its high therapeutic potential in psychiatry. In this study, we investigated the multifaceted aspects of psilocybin, highlighting its chemical properties, mechanisms of action, and burgeoning role in psychiatric treatment. Furthermore, we examined the clinical applications and potential therapeutic benefits of psilocybin in the treatment of various mental health disorders, supported by accumulating clinical evidence.

Development of the Diagnostic Matrix of the Seoul Cognitive Status Test, Compared to Traditional Paper-and-Pencil Neuropsychological Tests.

Background And Purpose: We aimed to develop the diagnostic matrix of the Seoul Cognitive Status Test (SCST) and compare its performance with traditional paper-and-pencil neuropsychological tests, including the Seoul Neuropsychological Screening Battery-II (SNSB-II) and the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K).

Methods: We recruited 197 participants from the head-to-head SCST-SNSB cohort, and 204 participants from the head-to-head SCST-CERAD cohort. They underwent either SNSB-II or CERAD-K, in addition to SCST.