Publications by authors named "Na Jiang"
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and an important cause of end-stage renal disease (ESRD). However, there is still a lack of effective prevention and treatment strategies in clinical practice. As a metabolic disease, DN is accompanied by renal ectopic lipid deposition, and the deposited lipids further aggravate kidney injury.
View Article and Find Full Text PDFThe transsulfuration (TSS) pathway is an alternative source of cysteine for glutathione synthesis. Little of the TSS pathway in antioxidant capacity in sickle cell disease (SCD) is known. Here, we evaluate the effects of TSS pathway activation through cystathionine beta-synthase (CBS) to attenuate reactive oxygen species (ROS) and ferroptosis stresses in SCD.
View Article and Find Full Text PDFAssociation of geriatric nutritional risk index with total testosterone in elderly adults in the US: evidence from NHANES 2011-2016.
Front Endocrinol (Lausanne)
December 2024
Background And Objectives: There is growing evidence that deficiencies in specific nutrients can impact testosterone levels in older men. However, research examining the predictive value of overall nutritional status on testosterone levels remains limited. The Geriatric Nutritional Risk Index (GNRI) is an effective tool for assessing the nutritional status of the elderly.
View Article and Find Full Text PDFObjective: While earlier research has indicated that trans fatty acids (TFAs) are detrimental to cardiovascular health as well as other conditions, the purpose of this study is to look into any possible connections between trans fatty acids and rheumatoid arthritis (RA).
Methods: The NHANES database provided the data for this study, covering two periods: 1999-2000 and 2009-2010. The correlation between plasma TFAs (linolelaidic acid, vaccenic acid, palmitelaidic acid, and elaidic acid) and RA was examined using weighted univariate and multivariate regression analyses as well as analysis of subgroups.
Sawdust is the cutting tailings produced during stone processing, which is difficult to deal with and has a huge stock. Therefore, it is particularly important to enhance the comprehensive utilization of sawdust. The aim of this study was to synergistically utilize sawdust with other industrial wastes (fly ash, silt, and red mud), add cement as a curing agent to prepare modified sawdust, and analyze its performance through an unconfined compressive strength test, dry and wet cycle tests, and SEM.
View Article and Find Full Text PDFBackground: The emergence of dengue fever has prompted significant public health responses, highlighting the need for a comprehensive understanding of One Health in addressing vector-borne diseases. China's experience in dengue control and prevention programs offers valuable insights into the successful integration of multidisciplinary strategies.
Aims: The review aims to: (1) systematically analyze lessons from China's dengue control and prevention programs, focusing on the integration of these efforts with the One Health approach; (2) underscore the reasons of optimizing the dengue control and prevention program; (3) highlight the alignment of China's dengue control strategies with the One Health framework; (4) contribute to global efforts in combating dengue, providing scientific evidence and strategic recommendations for other regions facing similar challenges.
Article Synopsis
- Carbon-based materials with a good balance of defects and microcrystals show potential as effective anode materials for sodium-ion batteries (SIBs), offering better capacity and conductivity.
- The molecular chemistry technique involving cross-linking and defect repair helps manage the trade-off between active sites and conductivity limitations in these materials.
- The resulting carbon material improves ion transfer and increases capacity significantly, from 162.5 to 336.5 mAh g, demonstrating a successful approach to enhancing SIB performance through microstructural regulation.
Article Synopsis
- T helper 2 (Th2) cells play a dual role in the body by fighting parasites and aiding tissue repair, but they can also cause problems in conditions like asthma and tissue fibrosis.
- Research showed that Th2 cells from asthma patients have increased levels of a protein called HIF2α, which is crucial for their pathogenic development.
- Targeting HIF2α could be a potential treatment strategy for asthma, as its inhibition was found to reduce harmful Th2 cell differentiation and decrease airway inflammation.
Article Synopsis
- The common carp, a key freshwater fish in aquaculture, is facing high mortality rates due to bacterial infections linked to intensive farming practices.
- The study analyzed the relationship between infection concentration and immune response by measuring mortality rates, serum LZM, IgM levels, and gene expression in the fish's head kidney.
- Findings revealed that higher pathogen concentrations correlated with increased mortality and immune markers, identifying numerous immune-related genes and pathways that are crucial for understanding carp’s immune response to infections.
Article Synopsis
- Bamboo is a significant nontimber forestry product that is influenced by abiotic stresses, and the study focuses on fatty acid desaturase (FAD) genes responsible for regulating plant tolerance to these stresses.
- Researchers identified 43 PeFAD genes in the moso bamboo genome, classifying them into six groups and finding that some structures are conserved, while gene expansion was linked to duplications.
- The study validated the cold-induced expression of specific PeFAD genes through qRT-PCR, marking the first comprehensive analysis of these genes and highlighting their potential for enhancing stress tolerance in bamboo breeding.
Article Synopsis
- The study examined how well blood pressure (BP) is controlled in primary care patients with hypertension, focusing on those with and without diabetes, from 2020 to 2023.
- Results showed that patients with diabetes and unstable BP were significantly less likely to maintain effective BP control compared to those without diabetes and stable BP.
- Factors like age, gender, waist-to-height ratio, weight status, alcohol consumption, and educational level were linked to BP control outcomes, indicating a need for targeted strategies to help manage BP effectively, particularly in patients with both hypertension and diabetes.
Article Synopsis
- Multiple sclerosis (MS) is a common neurodegenerative disease that leads to damage in the central nervous system, and its mechanisms are still being investigated using the EAE mouse model.
- In a recent study, researchers identified 744 proteins that change in the brain and 741 in the spinal cord of EAE mice, linking these proteins to processes like phagocytosis and inflammasome activation.
- The study also revealed that targeting SUMOylation, a process modified by a selective inhibitor called TAK-981, can reduce MS symptoms and provide insights for potential new treatments.
Article Synopsis
- The text discusses the challenges in creating synthetic populations for geo-simulation research, particularly the lack of social networks essential for studying human interactions like disease spread and disaster response.
- It introduces a new Python method that utilizes open data, including the 2020 U.S. Census, to generate a realistic synthetic population for all 50 states and Washington D.C., complete with stylized social networks.
- This synthetic population can be used in various geo-simulation models, such as agent-based modeling, to investigate complex phenomena and enhance research on urban digital twins.
Article Synopsis
- Ticks are important disease vectors, and this study examines the microbial communities in tick populations from Inner Mongolia to help develop strategies for controlling pathogen transmission.* -
- Researchers collected and analyzed tick samples using various identification and sequencing methods, revealing significant variations in bacterial composition based on geography and tick feeding status.* -
- The findings showed that certain ticks, particularly Dermacentor nuttalli, carried higher levels of pathogenic bacteria, highlighting their potential threat to health in the region.*
Article Synopsis
- Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly infectious and deadly virus characterized by immune dysfunction and aggressive viral replication.
- Research using MeRIP-seq has identified m6A modifications on SFTSV RNA, revealing that the protein YTHDF1 binds to these modifications and reduces the stability and translation of SFTSV proteins.
- The virulence factor NSs from SFTSV increases the lactylation and degradation of YTHDF1, promoting viral replication by countering the antiviral actions of the host's immune response.
[A clinical study on the optimal placement depth for peripherally inserted central catheter through the great saphenous vein in preterm infants].
Zhongguo Dang Dai Er Ke Za Zhi
October 2024
Objectives: To investigate the correlation between optimal placement depth (OPD) and physical measurement parameters in preterm infants receiving placement of peripherally inserted central catheter (PICC) through the great saphenous vein (GSV), and to establish a predictive formula for OPD during the placement of PICC through the GSV.
Methods: A retrospective analysis was performed for the preterm infants who received the placement of PICC through the GSV in the Neonatal Intensive Care Unit of the Third Xiangya Hospital of Central South University from December 2022 to February 2024. According to the site of puncture [GSV of the knee joint (KJ) or the ankle joint (AJ)], they were divided into a GSV-KJ placement group (=38) and a GSV-AJ placement group (=33).
Article Synopsis
- The study focuses on the Walker insect, a pest that threatens crops like bamboo and rice in China, potentially leading to significant economic losses.* -
- Using data from 234 locations and predicting under three climate scenarios, the MaxEnt and GARP models forecast changes in suitable habitats for the Walker insect, with varying trends through the 2050s and 2090s.* -
- The results indicate suitable areas for the insect may expand towards northern and southwestern China, particularly in regions like Sichuan, Chongqing, and Yunnan, prompting suggestions for increased monitoring by forestry authorities.*
Article Synopsis
- The study investigates the link between the triglyceride glucose (TyG) index and sarcopenia, specifically looking into how TyG can predict insulin resistance and its potential impact on muscle loss in older adults.
- Using data from a large cohort of over 10,500 participants aged 45 and older, the researchers employed various statistical methods to assess the association between TyG indices (including TyG-BMI and TyG-WC) and the risk of developing sarcopenia.
- The findings indicated that higher values of the TyG index were associated with a lower risk of sarcopenia, with the TyG-BMI showing particularly strong predictive ability for identifying individuals at risk.
Article Synopsis
- The study analyzes COVID-19 transmission in Western New York by integrating genomic sequencing data from patients with a SEIR computational model that considers geographical factors.
- *It investigates how genetic variations in the virus, along with population density and movement patterns, influence the spread of SARS-CoV-2 within specific regions.
- *The findings highlight local transmission dynamics, suggesting potential cross-county spread, and aim to inform better public health strategies for future virus control.*
Background: Pancreatic cancer is one of the most lethal malignancies, characterized by poor prognosis and low survival rates. Traditional prognostic factors for pancreatic cancer offer inadequate predictive accuracy, often failing to capture the complexity of the disease. The hypoxic tumor microenvironment has been recognized as a significant factor influencing cancer progression and resistance to treatment.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how nutrient enrichment affects soil microbial populations, focusing on the role of soil microorganisms in nutrient cycling processes.
- - Nitrogen addition promotes copiotrophic bacteria growth while hindering oligotrophic bacteria, whereas phosphorus addition alleviates deficiency and decreases certain bacterial populations.
- - The results highlight that changes in nutrient availability, particularly phosphorus, significantly affect soil bacterial diversity and may influence soil ecosystem biogeochemical cycles more than soil pH changes.
Article Synopsis
- The study investigates how ADAM17 affects angiogenesis and inflammation in endothelial cells, particularly in the context of high glucose levels typical in peritoneal dialysis patients.
- Researchers cultured human umbilical vein endothelial cells (HUVECs) and discovered that high glucose conditions increase ADAM17 expression, which in turn boosts inflammatory and angiogenic responses.
- Silencing ADAM17 reduced the expression of key inflammatory markers and hindered the migration and tube formation of HUVECs, suggesting that inhibiting this protein could mitigate negative effects in patients with peritoneal dialysis.
Article Synopsis
- - Severe fever with thrombocytopenia syndrome virus (SFTSV), now known as Dabie bandavirus, has a high fatality rate and poses a significant public health risk as a newly-identified bunyavirus.
- - The study found that methyl-beta-cyclodextrin (MβCD), a drug that disrupts cholesterol in lipid rafts on cell membranes, can inhibit SFTSV infection and affect the virus's ability to enter host cells.
- - MβCD not only impacted SFTSV entry by altering lipid raft structures but also decreased the infection risk in mice, highlighting its potential as a therapeutic treatment for SFTSV.