Publications by authors named "Na Huang"

The cytoskeleton of Drosophila tendon cells features specialized F-actin/microtubule arrays that endow these cells with resistance to the tensile forces exerted by the attached muscles. In a forward genetic screen for mutants with neuromuscular junction and muscle morphology phenotypes in larvae, we identified formin 3 (form3) as a crucial component for stabilizing these cytoskeletal arrays under muscle tension. form3 mutants exhibit severely stretched tendon cells in contact with directly attached larval body wall muscles, leading to muscle retraction and rounding.

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Introduction And Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly non-alcoholic fatty liver disease, is a growing global health challenge. This study examines the global burden of MASLD from 1990 to 2021 and projects data for 2045.

Materials And Methods: Using data from the Global Burden of Disease (GBD) Study 2021, the study analyzed MASLD across 204 countries from 1990 to 2021, focusing on prevalence, incidence, deaths, and disability-adjusted life years (DALYs).

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Purpose: Forkhead box P3 (FOXP3), a key marker of regulatory T cells (Tregs), is crucial for Treg differentiation and development. Emerging evidence suggests that FOXP3 is also expressed in various tumor cells; however, its role in tumor progression remains controversial. This study aimed to elucidate the impact of FOXP3 on breast cancer development.

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Purpose: Human epidermal growth factor receptor 2 (HER2)-low breast cancer has the potential to emerge as a distinct subtype. Several studies have compared the differences between HER2-low and HER2-0 breast cancers, but no consensus has been reached. Additionally, a biomarker to predict pathological complete response (pCR) rates in patients with HER2-low breast cancer remains to be identified.

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Background: Patients with microsatellite stable (MSS) colorectal cancer (CRC) often display resistance to immunotherapy. Epidermal growth factor receptor (EGFR)-targeted therapies have shown potential in enhancing immunotherapy, yet clinical benefits remain unfulfilled, which may relate to inadequate patient stratification.

Methods: Circulating tumor cells and tumor tissues were collected from multicenter cohorts of patients with CRC receiving cetuximab to analyze EGFR variant type III (EGFRvIII) expression and immune infiltration.

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Background: We aimed to develop a machine learning model based on intratumoral and peritumoral F-FDG PET/CT radiomics to non-invasively and dynamically predict the response to immunotherapy in non-small cell lung cancer (NSCLC).

Methods: This retrospective study included 296 NSCLC patients, including a training cohort (N = 183), a testing cohort (N = 78), and a TCIA radiogenomic cohort (N = 35). The extreme gradient boosting algorithm was employed to develop the radiomic models.

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Background: Dachaihu decoction (DCHD) is a common Chinese medicine formula against sepsis-induced acute lung injury (SALI). PANoptosis is a novel type of programmed cell death. Nevertheless, The mechanisms of DCHD against SALI via anti-PANoptosis remains unknown.

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Trichoderma is a widely distributed thermophilic fungus that grows on moist soil, fallen leaves, and rotten wood. It plays an important role in agricultural production, food processing, and soil. However, some forms of Trichoderma can infect humans.

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Liver metastasis is the main cause of cancer-related mortality. During the metastasis process, circulating carcinoma cells hardly pass through narrow capillaries, leading to nuclear deformation. However, the effects of nuclear deformation and its underlying mechanisms on metastasis need further study.

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The objective of this study was to compare chlorhexidine digluconate and other antibiotics susceptibility of four species of the complex, and further investigate the chlorhexidine digluconate (CHG) tolerance mechanisms and molecular epidemic characteristics. Of 889 complex isolates, , and accounted for 84.2%, 10.

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A palladium-catalyzed annulation reaction of bay-iodobiphenyls with maleimides was developed. This approach allows for the efficient synthesis of a variety of 9,10-phenanthrenedicarboximides, particularly polyalkoxy-substituted 9,10-phenanthrenedicarboximides with potential liquid-crystalline properties. Research findings indicate that the resulting product, -hexyl-2,3,6,7-tetrakis(hexyloxy)-9,10-phenanthrenedicarboximide, exhibits promising, good liquid-crystalline properties.

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Infected wounds caused by bacteria commonly cause delayed wound healing and even serious tissue damage, evolving into one of the most problematic clinical issues. Traditional therapies and wound dressings cannot achieve either the ideal antibiotic activity or the accelerated wound healing outcomes. Based on our previous finding that glycoproteins (PAGP) derived from medicinal animal insect Periplaneta americana L.

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Background: Sepsis is a critical condition characterized by multi-organ dysfunction (MODS) that presents significant treatment challenges. Traditional Chinese medicine (TCM), particularly Dachaihu decoction (DCH), has shown potential in addressing sepsis-related complications.

Purpose: To comprehensively evaluate the efficacy and safety of DCH in the treatment of sepsis.

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Drug resistance limits the efficacy of chemotherapy for colorectal cancer liver metastasis (CRLM). However, the evolution of CRLM during drug treatment remains poorly elucidated. Multi-omics and treatment response data from 115 samples of 49 patients with CRLM undergoing bevacizumab (BVZ)-based chemotherapy show little difference in genomic alterations in 92% of cases, while remarkable differences are observed at the transcriptomic level.

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With the development of transportation technology, the improvement of transportation efficiency also increases the complexity and diversity of traffic safety risks; the public's concern for traffic safety risks is increasing, and the traditional regulatory model is difficult to meet the improvement of the effectiveness of the safety regulation of the huge transportation network and the public's changing safety needs. In order to enhance the effectiveness of safety regulation, a game model of safety risk regulation among the public, transport enterprises, and regulators is constructed to simulate the effects of different traffic risks, penalty levels, and exposure rates on the behavior of transport enterprises and regulators. The results of the study show that: traffic risk has a positive facilitating effect on the participation of transport enterprises and the public in the regulation of safety risks, which will accelerate the process of stabilization of their strategies; transport enterprises have a high sensitivity to changes in the level of punishment, and only when the level of punishment exceeds a certain threshold will they be able to promote the choice of complying with the transport; and a higher exposure will lead to a greater tendency for transport enterprises to choose complying with the transport.

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Article Synopsis
  • Non-small cell lung cancer (NSCLC) is the most prevalent and lethal lung cancer, with its poor outlook linked to complex interactions in the tumor microenvironment.
  • The study utilized methylation analysis and high-throughput sequencing to investigate how methylation impacts mRNA characteristics and its regulatory effects on tumor-related genes.
  • Findings revealed that high levels of mRNA methylation correlate with changes in tumor microenvironment factors, affecting mRNA stability and translation, and resulting in worse prognosis for NSCLC patients.
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Introduction: Lung cancer is the leading cause of cancer-related death worldwide. The treatment for lung cancer, particularly for non-small cell lung cancer (NSCLC), remains a clinical challenge. Cancer stem cells are vital for lung cancer development.

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The purpose of this paper is to discuss how cross-border e-commerce enterprises can promote the sustainable development of the supply chain by optimizing the risk of supply disruption and product quality control mechanism of the cross-border supply chain of low-carbon agricultural products in the face of the problem of uneven quality and inventory shortage that prevails in the supply chain of low-carbon agricultural products under the framework of low-carbon economy. Methods: A two-level supply chain model consisting of a risk-averse cross-border e-commerce enterprise and two risk-neutral overseas suppliers is constructed to compare the optimal strategies and their coordination effects under the centralized and decentralized decision-making modes, and to deeply analyze the supply chain's operation mechanism. Further, the quality cost factor is introduced and an option contract model is designed to quantitatively analyze the impact of different decision-making scenarios and parameter changes on the overall supply chain performance.

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Obstruction of bile ducts due to gallstones can lead to biliary acute pancreatitis (BAP). According to Perides et al., G protein-coupled bile acid receptor-1 (GPBAR1) mediates BAP.

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Ethnopharmacological Relevance: Dachaihu decoction (DCH) is a famous and ancient TCM formula, extensively utilized for over 1800 years in treating gastrointestinal and inflammatory conditions. Our previous study showed that DCH ameliorated intestinal damage and modulated the gut microflora in septic rats. However, the material basis for these effects and the underlying mechanism of action remains ill-defined.

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Article Synopsis
  • A new reaction method using palladium as a catalyst was developed to combine bay-diiodinated arenes with -chloroaromatic carboxylic acids.
  • This technique allows for the production of various polycyclic aromatic compounds, particularly those with multiple alkoxy groups, which have applications in liquid-crystalline materials.
  • The study found that one of the resulting compounds, 2,3,8,9,12,13-hexakis(hexyloxy)-5-azadibenzo[fg,op]tetracene, shows promising liquid-crystalline properties at room temperature.
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Radiofrequency ablation (RFA), a form of thermal ablation, employs localized heat to induce protein denaturation in tissue cells, resulting in cell death. It has emerged as a viable treatment option for patients who are ineligible for surgery in various diseases, particularly liver cancer and other tumor-related conditions. In addition to directly eliminating tumor cells, RFA also induces alterations in the infiltrating cells within the tumor microenvironment (TME), which can significantly impact treatment outcomes.

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Article Synopsis
  • This study examines how surface roughness and Reynolds number (Re) impact fluid flow and solute transport in a double rough-walled fracture model simulating natural rock fractures.
  • As Re rises from 0.1 to 200, flow transitions from linear to nonlinear, causing complicated streamlines and eddies that create stagnant zones affecting solute movement.
  • The research finds that higher Re and joint roughness coefficient (JRC) increase non-Fickian transport characteristics, with traditional advection-diffusion models becoming less accurate at high Re, while the continuous time random walk (CTRW) model performs better across the entire Reynolds range.
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Article Synopsis
  • Researchers are studying how combining immunotherapy and radiotherapy (RT) affects cancer tumors, especially focusing on the tumor's environment and immune response.
  • They collected tumor samples from a patient with stomach cancer to see how different types of cells changed during RT using special techniques.
  • Their findings showed that while RT increases some immune cells, it also lowered the presence of others, suggesting careful planning is needed for effective cancer treatments combining RT and immunotherapy.
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Purpose: This study aimed to create and validate robust machine-learning-based prediction models for antipsychotic drug (risperidone) continuation in children and teenagers suffering from mania over one year and to discover potential variables for clinical treatment.

Method: The study population was collected from the national claims database in China. A total of 4,532 patients aged 4-18 who began risperidone therapy for mania between September 2013 and October 2019 were identified.

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