Publications by authors named "NOZDRACHEV A"

Change in the diffuse portion of the double electric layer at the blood-vascular wall border under the effect of thorium nitric oxide and heparin affects the tone and contractile ability of the rat tail artery: thorium diminishes the vessel rigidity and the amplitude of its contractile response, whereas heparin augments the rigidity as well as the amplitude of the response. Thorium nitric oxide also diminishes rigidity of the vessel connective tissue skeleton. The difference of potentials between the vessel lumen and its wall seems to be capable of affecting the contractile apparatus of the smooth muscle cells by means of activation of potential-sensitive ionic channels.

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The process of sympathectomy of white rats was achieved by injecting guanethidine intraperitoneally every day for 5.5 weeks at doses of 75 mg/kg of animal's weight. This process of sympathectomy was checked according to ganglion cervicothoracicum neurocytes state.

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Using the complex of histological methods (staining with toluidine blue, silver nitrate impregnation and application of retrograde fluorescent dye primulin) the data on the neural elements spatial localization within Peyer patches of the small intestine and their connections with the rest of enteric metasympathetic nervous system in rat was obtained. Submucosal plexus that is significantly developed within this lymphoid organ and is divided into internal and external plexuses was found to be most essential to the innervation of rat Peyers patches. These plexuses innervate all Peyers patch areas:nodules, cupula and internodular zones and the nodule-associated epithelium.

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Some structural and functional peculiarities of the rat vestibular nuclei neurones involved in realisation of vestibular-gastrointestinal reflectory reactions were studied. After microinjection of a horseradish peroxidase solution in the 'gastric' area of the nucleus tractus solitarius, retrogradely-labelled cell bodies were found in caudal part of the medial vestibular nucleus. Electrical stimulation of these neurons resulted in the decrease of gastric tone.

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Neurons of cuneiform, subcuneiform, medial parabrachial, median raphe nuclei were studied. 26-47% units were found to send monosynaptic inputs to the raphe magnus nucleus, gigantocellular reticular and ventral reticular nuclei. 17-43% responded to stimulation of the inhibitory brain stem areas with excitatory-inhibitory reactions.

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The stages of degeneration and regeneration of the receptor system of sole skin after cryogenic damaging of the nerve were investigated using the method of impulse activity registration from single fibres of white rat sciatic nerve in acute experiment under hexenal anesthesia. The mechanism of pain syndrome and peculiarities of the development processes of the nerve and skin receptors repair after cryogenic trauma are discussed.

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Stress-induced functional changes in the light pinealocytes and signs of stress-limiting effect of oxytocin were revealed in white non-linear rats. The data obtained suggests involvement of oxytocinergic systems in the stress modulation of pinealocytes.

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