Primary adenocarcinoma arising in an ileostomy.

Two cases are added to the world literature of patients in whom an adenocarcinoma developed at the ileostomy site after total proctocolectomy for ulcerative colitis. Fourteen additional cases have been reported in the world literature; of these, 12 cases have been in patients with ulcerative colitis, and four cases have been in patients with familial adenomatous polyposis. Adenocarcinoma of an ileostomy is not common.

Morbidity and mortality following abdominoperineal resection for rectal adenocarcinoma.

From 1979 through 1986, 56 patients, 38 males (68%) and 18 females (32%), underwent an abdominoperineal resection with a wide perineal dissection for primary adenocarcinoma of the rectum. The open perineal wounds required a mean time of 6 months to completely heal. Estimated blood loss by the surgeon ranged from 200 ml to 4200 ml with a mean of 1112 ml and a median of 1000 ml.

Evaluation of alpha-difluoromethylornithine as a potential chemopreventive agent: tolerance to daily oral administration in humans.

An initial clinical trial of alpha-difluoromethylornithine given p.o. daily for 6 months was carried out in 27 subjects free of disease following surgery for malignancy or in a defined high-risk group for cancer.

Isolation of Inoue-Melnick virus from colorectal carcinoma tissues.

Background: Isolation of Inoue-Melnick virus (IMV) Type 1 from tumor tissues of patients with colorectal carcinoma in Japan was reported. A high prevalence of IMV antibodies has been found among patients with colorectal carcinoma in Buffalo, New York.

Methods: IMV was isolated from homogenates of colorectal carcinoma and other tissues, inoculated into MRC-5 human fibroblast cultures.

Problems encountered in teaching the use of the 65 cm flexible sigmoidoscope in a surgical oncology training program.

Flexible sigmoidoscopy after age 50 has been recommended by the American Cancer Society for colorectal cancer screening. A questionnaire to assess the difficulties encountered in learning to perform this procedure was given to 19 surgical oncology fellows after a 3-month rotation in the Division of Colorectal Surgery. Sixteen (84%) trainees related that between 10-20 flexible sigmoidoscopies were necessary before they felt competent.

Endoscopic laser treatment for palliation of colorectal adenocarcinoma.

Fifty-three patients were treated for palliation with endoscopic neodymium yttrium aluminum garnet (Nd:YAG) laser for colorectal carcinoma at Roswell Park Cancer Institute. There were 25 females and 28 males. The mean age of the patients was 76 years.

Altered immunoglobulin A (IgA-1) levels in patients with advanced colorectal adenocarcinoma presenting with normal preoperative levels of carcinoembryonic antigen (CEA).

We investigated the value of serum IgA-1 as a complementary tumour marker to carcinoembryonic antigen (CEA) in the monitoring of the postoperative follow-up of 19 patients with advanced colorectal carcinoma presenting with normal levels of CEA. Mean follow-up period was 14 months (range 2-72 months). Mean number of serum specimens was 5 (range 2-9).

Results of surgical resection of pulmonary metastases of squamous cell carcinoma of the head and neck.

In this retrospective review of 58 patients (12 females and 46 males) with pulmonary metastases of squamous cell carcinoma of the head and neck treated between January 1, 1970, and December 31, 1989, we evaluated their clinical courses and analyzed the outcomes of those who underwent pulmonary resection. For the entire group of patients, factors predictive of survival in those patients with a diagnosis of pulmonary metastases included pulmonary resection of metastases (p = 0.0001), locoregional control of the head and neck primary tumor at the time of diagnosis of pulmonary metastases (p = 0.

Photodynamic therapy in the management of neoplasms of the perianal skin.

Perianal extramammary Paget's disease, Bowen's disease, and squamous cell carcinoma are three entities that are very rarely reported. Overall, it is generally accepted that wide surgical excision is adequate treatment except under certain circumstances. Consideration has to be given to invasiveness, metastatic potential, multicentricity, and tendency to recur.

Resection of lung metastases from soft-tissue sarcomas. A multivariate analysis.

From 1970 through 1986, 78 patients underwent 162 thoracotomies for removal of lung metastases from soft-tissue sarcomas. A multivariate analysis showed that the presence of a local recurrence, an incomplete pulmonary resection, and a shorter disease-free interval were poor prognostic factors. Patients who underwent multiple thoracotomies survived longer from the time of initial thoracotomy.

99mTc-IMMU-4 monoclonal antibody scan in colorectal cancer. A prospective study.

A blinded prospective study of 34 patients with colorectal adenocarcinoma using the Fab' fragment of the anticarcinoembryonic antigen monoclonal antibody type IMMU-4 labeled with technetium 99m was conducted to compare, on a lesion-by-lesion basis, the findings of radioimmunoscintigraphy, preoperative computed tomography, and exploratory celiotomy. Of 115 lesions detected at surgery, 113 were adenocarcinoma. Radioimmunoscintigraphy detected 59 lesions and computed tomography detected 62; both studies combined detected 72.

The use of the major anoxic stress response protein P34, the K isozyme of lactate dehydrogenase, and carcinoembryonic antigen in the follow-up of patients with colorectal adenocarcinoma.

Background: This prospective study evaluated the use of the K isozyme of lactate dehydrogenase (LDH-K) as a complementary tumor marker to carcinoembryonic antigen (CEA) in patients with colorectal adenocarcinoma.

Methods: In this series, 355 patients underwent potentially curative surgery for primary colorectal adenocarcinoma. A close surveillance program of follow-up revealed 108 patients (30%) who had a serum elevation in CEA and/or LDH-K.

Gastroduodenal polyps in familial adenomatous polyposis.

A retrospective review of the medical records of 30 patients with familial adenomatous polyposis who underwent oesophagogastroduodenoscopy was performed to evaluate the spectrum of gastroduodenal polyps. Twenty-five patients (83%) had gastroduodenal polyps. Eighteen patients (60%) had gastric polyps and 21 patients (70%) had duodenal polyps.

Prognostic significance of anastomotic recurrence from colorectal adenocarcinoma.

A retrospective analysis of the prognostic significance of anastomotic recurrence in 50 patients with colorectal adenocarcinoma was conducted from 1970 to 1987. All primary cancers were located above 10 cm from the anal verge. Forty anastomotic recurrences (80 percent) followed resection of sigmoid or proximal rectal tumors.

High prevalence of Inoue-Melnick virus antibodies in patients with colorectal carcinoma.

The high prevalence of serum neutralizing antibodies against Inoue-Melnick virus (IMV) among American patients with colorectal carcinoma has been confirmed. Sera from 26 patients with colorectal carcinoma along with the identical number of age- and sex-matched patients with non-colorectal neoplasia and normal healthy controls were collected in the Buffalo area. All of the colorectal carcinoma group possessed antibodies against IMV (100%), while antibody positivity for non-colorectal neoplasia and for normal controls were 34.

Surgery for recurrent rectal adenocarcinoma in the presence of hydronephrosis.

From January 1974 to December 1989, 16 patients with locally recurrent rectal adenocarcinoma and hydronephrosis underwent exploratory celiotomy with curative intent. There were eight males and eight females. The median age was 61 years.

The utility of squamous cell carcinoma antigen for the follow-up of patients with squamous cell carcinoma of the anal canal.

Background: Thirty-three patients with histologic documentation of squamous cell carcinoma (SCC) of the anal canal underwent prospective serial collection of 234 serum samples for radioimmunoassay of SCC tumor-associated antigen.

Methods: There were 23 female and 10 male patients, with a median age of 55 years. Twenty-two of the 33 patients had multimodality therapy with radiation therapy and chemotherapy as initial treatment.

Technique for packing the perineal wound after a wide perineal dissection for adenocarcinoma of the rectum.

A technique for packing the perineal wound after a wide perineal dissection performed as part of an abdominoperineal resection is described. An isolation bag is filled with rolled gauze and positioned in the pelvis beneath the sacral promontory. The packing and the bag are removed on the fifth postoperative day.

Morbidity and mortality after pelvic exenteration for colorectal adenocarcinoma.

A retrospective analysis was made of the complications from pelvic exenterations performed over the past 30 years for colorectal adenocarcinoma at the Roswell Park Cancer Institute. Seventy-five patients underwent exenteration, 51 for primary disease (PD) and 24 for recurrent disease (RD). Both total and posterior exenterations were included.

Patterns of recurrence after pelvic exenteration for colorectal adenocarcinoma.

We performed a retrospective review of 68 patients who underwent pelvic exenteration for colorectal adenocarcinoma. Forty-seven patients had surgery for primary disease and 21 for recurrence. Clinical recurrence developed in 30 (44%) of 68 patients overall.

Intrathecal phenol rhizotomy for management of pain in recurrent unresectable carcinoma of the rectum.

The medical records of 11 patients with recurrent unresectable adenocarcinoma of the rectum who had intrathecal phenol block for the management of intractable pain were reviewed. There were seven patients with pelvic and four with combined pelvic and perineal recurrences. Five patients had sacral involvement by tumor.

Colorectal adenocarcinoma in patients less than 40 years of age.

From 1973 to 1985, 105 patients under 40 years of age were treated for colorectal adenocarcinoma at Roswell Park Cancer Institute. There were 51 males and 54 females. The mean age was 32 years.

Primary de novo adenocarcinoma of the colon measuring 8 mm in diameter with lymph node metastases. Report of a case.

Colonic adenocarcinomas measuring less than 10 mm are rare. Herein, we report a carcinoma measuring 8 mm in diameter associated with subserosal extension through a "locus minoris resistentiae" and metastases to lymph nodes, an association not previously reported. No residual adenomatous tissue was found, suggesting a de novo carcinoma.