Nurses' experiences of providing digital and in-person healthcare support to children living with complex chronic conditions.

Objectives: To demonstrate how nurses in pediatric care provide information and maintain access to health care for children with complex chronic conditions utilizing e-health or in-person support methods.

Methods: The study involved 12 nurses/specialist nurses from the medical departments at Queen Silvia Children's Hospital in Gothenburg. A qualitative method was employed, using individual interviews with a semi-structured guide and analyzed using a reflexive thematic analysis method.

Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae using a laboratory-developed high-throughput test for the Panther Fusion system.

Mycoplasma pneumoniae and Chlamydia pneumoniae are key agents of atypical pneumonia. During a 2023 M. pneumoniae outbreak in Denmark, a high-throughput laboratory-developed test (LDT) was created for the Hologic Panther Fusion system using Open Access software.

Ecosurveillance reveals subtle metabolic effects on the non-native cane toad (Rhinella marina) from low levels of accumulated environmental per- and polyfluoroalkyl substances.

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment, bioaccumulate, and may have toxic effects. This study used non-native cane toads (Rhinella marina) to examine PFAS and metal accumulation and impacts in large terrestrial amphibians from urban and peri-urban areas. We quantified 38 PFAS compounds and 36 environmental and legacy metal(loid)s in 52 adult cane toad livers collected from six locations around Southeast Queensland, Australia, along a known PFAS gradient.

Unraveling the role of early coeliac disease diagnosis in the risk of developing immune-mediated renal diseases.

Background: coeliac disease (CD) is an inflammatory condition of the small intestine caused by immunological intolerance towards dietary gluten. Associations between CD and other autoimmune disorders have been extensively reported. However, the risk in CD patients of developing immune-mediated renal diseases (IMRDs) as a function of the duration of exposure to gluten remains uncharacterized.

Automated behavioral profiling using neural networks reveals differences in stress-like behavior between cave and surface-dwelling .

Behavioral stress responses allow animals to quickly adapt to local environments and are critical for survival. Stress responses provide an ideal model for investigating the evolution of complex behaviors due to their conservation across species, critical role in survival, and integration of behavioral and physiological components. The Mexican cavefish () has evolved dramatically different stress responses compared to river-dwelling surface fish morphs, providing a model to investigate the neural and evolutionary basis of stress-like responses.

Serum concentrations of PFAS across Australian States and Territories.

Background: Australia's long running human biomonitoring (HBM) program has provided information on per and poly-fluoroalkyl substances (PFAS) serum concentrations in the general population since 2002. The program is based on pooling and analysis of surplus, de-identified, pathology specimens predominantly sourced from Australia's north-eastern state Queensland (QLD). To date, potential nationwide spatial differences across Australia have not been assessed.

Number of Carbons Is a Critical Parameter for Accumulation of Per- and Polyfluoroalkyl Substances in the Human Brain.

Per- and polyfluoroalkyl substances (PFAS), a large group of manmade chemicals, have been detected extensively in the blood of people living in developed countries. Although it has been suggested that PFAS exposure might be associated with harmful effects on the brain, few studies have assessed the presence of PFAS in brain tissues. This study aimed to evaluate the concentrations of a broad range of PFAS in paired postmortem human brain and serum samples and investigate brain-to-serum concentration ratios.

Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty.

Objective: It can be challenging to determine the correct dosage of recombinant growth hormone (GH) in children with GH deficiency, leading to highly variable treatment responses. Insulin-like growth factor-1 (IGF-1) is a tool for monitoring GH treatment and dosing. However, IGF-1 levels depend on sex, age, and pubertal stage, amongst other factors, making its interpretation somewhat difficult.

Long-Term Outcome of Chronic Hepatitis B-Histological Score and Viral Genotype Are Important Predictors of Hepatocellular Carcinoma.

Current guidelines to prevent hepatocellular carcinoma (HCC) by chronic hepatitis B virus (HBV) infection are based on risk assessments that include age, sex, and virological and biochemical parameters. The study aim was to investigate the impact of predictive markers on long-term outcomes. The clinical outcomes of 100 patients with chronic hepatitis B were investigated 30 years after a baseline assessment that included liver biopsy.

Incidence and Risk Factors for Varicella-Zoster Virus-Associated Central Nervous System Infections: A Nationwide Swedish Retrospective Case-Control Study.

The determinants of varicella-zoster virus (VZV)-associated central nervous system (CNS) infection have not been fully elucidated. This study aimed to investigate the incidence and risk factors, including immunosuppression, for different manifestations of VZV-associated CNS infection. Patient registers were used to include adults diagnosed with VZV-associated CNS infections between 2010 and 2019 in Sweden.

Validity and reliability of the Swedish version of the Visual CARE Measure for assessing children's perceptions of nurses' empathy.

Unlabelled: The purpose of this study was to translate and validate a questionnaire to be used by children with chronic diseases during procedures. Specific research questions were as follows: Is the translated versions reliable? Is there a correlation between VCM and another questionnaire measuring discomfort to enhance the validity of VCM? The three versions of Visual CARE measure (VCM) were translated following the principles of good practice for translation and cultural adaptation of patient-reported outcome measures, according to the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Cognitive debriefing interviews with children, parents, and healthcare professionals were carried out.

Accelerating Plasmonic Hydrogen Sensors for Inert Gas Environments by Transformer-Based Deep Learning.

Rapidly detecting hydrogen leaks is critical for the safe large-scale implementation of hydrogen technologies. However, to date, no technically viable sensor solution exists that meets the corresponding response time targets under technically relevant conditions. Here, we demonstrate how a tailored long short-term transformer ensemble model for accelerated sensing (LEMAS) speeds up the response of an optical plasmonic hydrogen sensor by up to a factor of 40 and eliminates its intrinsic pressure dependence in an environment emulating the inert gas encapsulation of large-scale hydrogen installations by accurately predicting its response value to a hydrogen concentration change before it is physically reached by the sensor hardware.

Dried blood spot: A diagnostic detection method for HBV, HCV and HIV nucleic acid using a single drop of blood.

The global strategy to eradicate Hepatitis B (HBV), Hepatitis C (HCV), and HIV by 2030 is critical due to their impact and challenges to healthcare systems. HCV is curable, but HBV and HIV are only suppressible, with a vaccine available solely for HBV. Innovative diagnostic methods are needed, especially for high-risk populations like people who inject drugs (PWID).

Photofragmentation laser-induced fluorescence imaging of CH by structured illumination in a plasma discharge.

Methyl is crucial in plasma-assisted hydrocarbon chemistry, making precise in situ imaging essential for understanding various plasma applications. Its importance in methane chemistry arises from its role as a primary byproduct during the initial phase of methane dehydrogenation. Detecting the CH radical is challenging due to its high reactivity and the prevalence of strongly pre-dissociative electronically excited states.

Trends of Benzotriazoles and Benzothiazoles in Australian Pooled Urine Samples from 2012 to 2023.

Benzotriazoles (BZTs) and benzothiazoles (BTs) are high-production-volume chemicals utilized in many different commercial products and industrial processes, such as metal corrosion inhibitors, vulcanization accelerators, plastic-associated UV stabilizers, and pharmaceutical precursors. This study assessed age, gender, and temporal trends of BZTs and BTs in deidentified surplus pathology urine samples, pooled and stratified by age, gender, and sample collection year from a general Australian population (168 pools representing 16,800 individuals). Tolyltriazole (TTri), 5,6-dimethyl-1H-benzotriazole (DMBZT), 1,3-benzothiazole (BTH), 2-hydroxybenzothiazole (2-OH-BTH), and 2-aminobenzothiazole (2-amino-BTH) were detected in >50% of the pools.

Assessing the Usage and Usability of a Mental Health Advice Telephone Service in Uganda: Mixed Methods Study.

Background: Harnessing mobile health (mHealth) solutions could improve the delivery of mental health services and mitigate their impact in Uganda and similar low-resource settings. However, successful adoption requires that mHealth solutions have good usability. We have previously implemented a telephone service to provide mental health information and advice in English and Luganda, utilizing an automated interactive voice response (IVR) system linked to live agents, including mental health care workers and peer support workers.

Positive effects of tactile massage for adolescents with Attention Deficit/Hyperactivity Disorder (ADHD) - A small scale study.

Background And Purpose: Epidemiological studies show the prevalence of attention deficit hyperactivity disorder (ADHD) in adolescents is around 5 %. There is strong evidence for psychosocial interventions and medication for treatment of ADHD core symptoms, but these alone do not always reach a satisfactory outcome. The aim of this small-scale study was to evaluate the impact of tactile massage on ADHD core symptoms in adolescents in a clinical setting.

A 2-year follow-up to a randomized controlled trial on resistance training in postmenopausal women: vasomotor symptoms, quality of life and cardiovascular risk markers.

Background: Most women experience vasomotor symptoms (VMS) during the menopausal transition. A 15-week resistance training intervention (RTI) significantly reduced moderate-to-severe VMS (MS-VMS) and improved health-related quality of life (HRQoL) and cardiovascular risk markers in postmenopausal women. Whether a short RTI could have long-term effects is unknown.

Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice.

Aims: Angiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase to regulate tissue fatty acid (FA) uptake from triglyceride (TG)-rich lipoproteins such as very low density lipoproteins (VLDL). While pharmacological inhibition of ANGPTL3 is being evaluated as a lipid-lowering strategy, systemic ANGPTL4 inhibition is not pursued due to adverse effects. This study aims to compare the therapeutic potential of liver-specific Angptl3 and Angptl4 silencing to attenuate hyperlipidemia and atherosclerosis development in APOE*3-Leiden.

Depression of cortical neuronal activity after a low-dose fentanyl in preterm infants.

Aim: Opioids might be harmful to the developing brain and dosing accuracy is important. We aimed at investigating fentanyl effects on cortical activity in infants using computational re-analysis of bedside recorded EEG signals.

Methods: Fifteen infants born at median 26.

Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial.

Background: Venipuncture is one of the most commonly performed medical procedures in paediatric care, but it can also be one of the most painful and distressing experiences for patients. Finding effective strategies to manage pain and fear associated with venipuncture is crucial for improving the paediatric patient experience and promoting positive health outcomes. This study aimed to evaluate the efficacy of a combined approach using a topical analgesic cream (TKTX cream) and a distraction technique (Trace Image and Colouring for Kids-Book, TICK-B) in reducing pain intensity and fear levels in children undergoing venipuncture procedures.

Shigella and Enterotoxigenic Escherichia coli Have Replaced Rotavirus as Main Causes of Childhood Diarrhea in Rwanda After 10 Years of Rotavirus Vaccination.

The causes of diarrhea after 10 years of rotavirus vaccination in Rwanda were investigated with real-time polymerase chain reaction in 496 children with diarrhea and 298 without. Rotavirus was detected in 11% of children with diarrhea (odds ratio, 2.48; P = .