[The nature of hematopoiesis in animals with experimentally depressed immune system: natural and bifidumbacterin-induced recovery].

An attempt was made to examine the regulatory effect of bifidumbacterin on the recovery of immunological and hemopoietic homeostasis in mice. Bifidumbacterin feeding to healthy animals had no effect, except for the below-normal values reaching the statistically mean characteristic of mice of this strain. Bifidumbacterin stimulated lymphoiesis in animals immunocompromized by the administration of antilymphocytic antibodies or radiation, but the values being no higher than the normal ones.

[Immunomodulating action of eubiotics].

The study was undertaken to study the immunomodulating action of 3 bacterial agents: bifidumbacterin, acylact, and biosporine used in various abnormalities accompanied by intestinal dysbacteriosis. Surveys were made of children permanently residing in the radionuclide-contaminated areas of the Bryansk Region, those from northern areas of the Russian Federation, those who suffered from atopic dermatitis; adult patients with severe systemic disease (chronic postinfection polyarthritis); chronic adult patients with spinal injury due to compression fractures of the spinal cord. The immunological parameters in all the above patient groups were shown to differ in the lower absolute or relative counts of most lymphocytic populations.

[Isolation of antilymphocytic antibodies with the aid of cellular immunosorbents].

The authors suggest a method of obtaining purified antilymphocytic antibodies by mean of a specific immunosorbent of human or mouse lymphocytes fixated with glutharic aldehyde Such immunosorbents subjected to special treatment could be used repeatedly; their sorptive capacity was retained in such case. Only from 5 to 12% of the activity could be obtained from immunosorbents sorbed from the serum with 77--93% activity. In comparison with the initial serum, purification was from 6- to 15-fold.