24-hour blood pressure control by once-daily administration of irbesartan assessed by ambulatory blood pressure monitoring. Irbesartan Multicenter Investigators' Group.

Objectives: To compare 24 h ambulatory blood pressure and trough office blood pressure lowerings after 8 weeks of therapy with 75 mg irbesartan once a day, 150 mg irbesartan once a day , and 75 mg irbesartan twice a day versus placebo; and to assess safety and tolerability of irbesartan therapy.

Design: Multicenter, double-blind, randomized, placebo-controlled trial.

Setting: Sixteen centers in Italy.

[Long-term treatment with a new antihypertensive drug: flutonidin].

The aim of this research was to evaluate the effectiveness and the tolerability of flutonidin: a new clonidine-like antihypertensive compound. 30 patients (9 man and 21 women, mean age 60.5), affected by mild-moderate essential hypertension, have been randomized in two homogeneous groups of 15 patients, and treated respectively with flutonidin (F) 2 mg/day and clonidine (C) 0.