The pathogenesis of depression: Roles of connexin 43-based gap junctions and inflammation.

Background: Depression is a leading chronic mental illness worldwide, characterized by anhedonia and pessimism. Connexin is a kind of widely distributed protein in the body. Connexin 43 (Cx43) plays an important role in the pathogenesis of depression.

Filicinic Acid-Based Meroterpenoids with Antiproliferative Activity against Prostate Cancer PC-3 Cells from .

Nine new structurally diverse filicinic acid-based meroterpenoids (-) with four kinds of carbon skeletons were isolated from the rhizomes of . Their structures, including the absolute configurations, were elucidated by comprehensive analysis of spectroscopic data, quantum chemical calculations, and single-crystal X-ray diffraction. Structurally, compounds - feature an unprecedented 6/6/5/6/6/6 hexacyclic system with a rare oxaspiro[4.

Comparative analysis of sleep physiology using qualitative and quantitative criteria for insomnia symptoms.

Despite decades of research, defining insomnia remains challenging due to its complex and variable nature. Various diagnostic systems emphasize the chronic nature of insomnia and its impact on daily functioning, relying heavily on patient self-reporting due to limitations in objective measures like polysomnography (PSG). Discrepancies between subjective experiences and objective PSG results highlight the need for more nuanced approaches, such as electroencephalogram (EEG) spectral analysis, which reveals distinct patterns of high-frequency activity in individuals with insomnia.

Smartphone Application Intervention on Obstructive Sleep Apnea Among Overweight and Obese High-Tech Employees: A Randomized Controlled Trial.

The aim of this study was to examine the effectiveness of an adjusting lifestyle intervention with a smartphone application (app) in managing obstructive sleep apnea (OSA) among overweight and obese high-tech employees. A 6-months three-armed randomized controlled trial was employed. A total of 144 eligible participants were randomly allocated into the smartphone app 'MyFitnessPal' plus education (MFPE; n = 48), 'MyFitnessPal'-only (MFP-only; n = 50) and the control group (n = 46) at a 1:1:1 ratio.

Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle.

Emerging evidence shows that psychological stress promotes the progression of Parkinson's disease (PD) and the onset of dyskinesia in non-PD individuals, highlighting a potential avenue for therapeutic intervention. We previously reported that chronic restraint-induced psychological stress precipitated the onset of parkinsonism in 10-month-old transgenic mice expressing mutant human α-synuclein (αSyn) (hαSyn A53T). We refer to these as chronic stress-genetic susceptibility (CSGS) PD model mice.

Delayed Onset Bilateral Vocal Cord Palsy in Miller Fisher Syndrome: The Rehabilitation Outcome.

Miller Fisher syndrome (MFS) typically presents with acute development of ataxia, ophthalmoplegia, and areflexia. Bilateral vocal cord palsy (BVCP) is a rare manifestation of MFS. We present a case of a 66-year-old male diagnosed with MFS complicated by an unusually delayed onset of BVCP while undergoing inpatient rehabilitation.

Enhancing DSSCs and Photocatalytic Hydrogen Production with D-A-A-π-A Sensitizers Containing 10'H-Spiro [Fluorene-9,9'-Phenanthren]-10'-one and Benzo[c][1,2,5]Thiadiazole.

Novel D-A-A-π-A organic sensitizers (FZ-sensitizer), utilizing spiro [fluorene-9,9'-phenanthren]-10'-one and benzo [c][1,2,5]thiadiazole moiety as two auxiliary acceptors, are synthesized and applied in dye-sensitized solar cells (DSSCs) and hydrogen production. By incorporating a bulky spiro [fluorene-9,9'-phenanthrene]-10'-one (A) and benzo[c][1,2,5]thiadiazole (A) between the donor (D) and π-bridge moiety, structural modifications inhibit molecular aggregation, while the carbonyl group enhances the capture of Li ions, thereby delaying charge recombination. Furthermore, the extended π-conjugation broadens the light absorption range and enhances the power conversion efficiency (PCE) of FZ-2 under AM1.

The function of astrocytes and their role in neurological diseases.

Astrocytes have countless links with neurons. Previously, astrocytes were only considered a scaffold of neurons; in fact, astrocytes perform a variety of functions, including providing support for neuronal structures and energy metabolism, offering isolation and protection and influencing the formation, function and elimination of synapses. Because of these functions, astrocytes play an critical role in central nervous system (CNS) diseases.