Synthesis by deamination reaction and crystal structure at 120 K of (16,19)-18-oxo--(pyridin-2-yl)-6,7,9,10-tetra-hydro-18-dibenzo[,][1,4,7]trioxa-cyclo-hexa-decine-17-carboxamide.

The title compound, CHNO, is a product of the deamination reaction from aza-14-crown-4 ether containing the γ-piperidone subunit. The title mol-ecule contains a 16-membered macrocycle with the conformation of the C-O-C-C-O-C-C-O-C polyether chain being - --- - ( = , 180°; = , ±60°). The dihedral angle between the planes of the benzene rings fused to the aza-14-crown-4-ether moiety is 31.

Hydrogen-Bonding UCST-Thermosensitive Nanogels by Direct Photo-RAFT Polymerization-Induced Self-Assembly in Aqueous Dispersion.

Hydrogen-bonding upper critical solution temperature (UCST) thermosensitive nanogels based on poly(N-acryloyl glycinamide) (PNAGA) are synthesized by photo-reversible addition-fragmentation chain transfer mediated polymerization-induced self-assembly (photo-RAFT PISA) in aqueous dispersion using N,N'-methylenebis(acrylamide) as crosslinker and poly(oligo(ethylene glycol) methyl ether acrylate) as both stabilizer and macromolecular chain transfer agent (macro-CTA). Highly stable, spherical nanogels with narrow polydispersity are efficiently produced up to complete monomer conversion within 1 h under UV irradiation at low temperature (3 °C). The thermosensitive behavior of PNAGA-based nanogels, as assessed by dynamic light scattering and UV-vis spectrophotometry, exhibits reversible heating-induced swelling and cooling-induced shrinking corresponding to the expected UCST behavior.