Microbial manganese redox cycling drives co-removal of nitrate and ammonium.

Manganese (Mn), abundant in the Earth's crust, can act as an oxidant or a reductant for diverse nitrogen biotransformation processes. However, the functional microorganisms and their metabolic pathways, as well as interactions, remain largely elusive. Here, a microbial consortium was enriched from a mixture of freshwater sediments and activated sludge by feeding ammonium, nitrate and Mn(II), which established manganese-driven co-removal of nitrate and ammonium with removal rates of 5.

Randomized Controlled Trials for Platelet-Rich Plasma Use in Knee Osteoarthritis Rarely Report Key Sociodemographic Patient Variables: A Scoping Review.

Purpose: To investigate the characteristics and rate of sociodemographic variables reported in randomized controlled trials (RCTs) studying platelet-rich plasma (PRP) injections in the treatment of knee osteoarthritis (OA).

Methods: In January 2024, PubMed, Scopus, and Web of Science databases were queried for the phrase "Platelet-Rich Plasma Knee Osteoarthritis." Included studies were RCTs investigating PRP use in knee OA published in English between 2012 and 2023.

Effects of Biological Nitrogen Fixation and Nitrogen Deposition on Soil Microbial Communities in Karst Grassland Ecosystems.

Diverse exogenous nitrogen (N) sources have a considerable impact on microbial community structure in terrestrial ecosystems. Legume plants and N deposition can relieve N limitations and increase net primary productivity. However, the differences in their effects on soil microbial communities remain unclear.

Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis.

Background: Muscle-invasive bladder cancer (MIBC) is a prevalent cancer characterized by molecular and clinical heterogeneity. Assessing the spatial heterogeneity of the MIBC microenvironment is crucial to understand its clinical significance.

Methods: In this study, we used imaging mass cytometry (IMC) to assess the spatial heterogeneity of MIBC microenvironment across 185 regions of interest in 40 tissue samples.

Deficiency of Endothelial Impairs Pulmonary Vascular Angiogenesis and Predisposes Pulmonary Hypertension.

Background: Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the role of Piezo2 in PH remains unclear.

Methods: Endothelial cell (EC)-specific knockout (, Tek-Cre; ) rats and primarily cultured pulmonary microvascular ECs were used to determine the role of Piezo2 in PH.

Promoting defect formation and inhibiting hydrogen evolution by S-doping NiFe layered double hydroxide for electrocatalytic reduction of nitrate to ammonia.

Activation of HO cleavage for H* production by defect engineering eliminates the insufficient supply of protons in the NORR process under neutral conditions. However, it remains challenging to precisely control the defect formation for optimizing the equilibrium between H* production and H* binding. Here, we propose a strategy to boost defect generation through S-doping induced NiFe-LDH lattice distortion, and successfully optimize the balance of H* production and binding.

Towards designing improved cancer immunotherapy targets with a peptide-MHC-I presentation model, HLApollo.

Based on the success of cancer immunotherapy, personalized cancer vaccines have emerged as a leading oncology treatment. Antigen presentation on MHC class I (MHC-I) is crucial for the adaptive immune response to cancer cells, necessitating highly predictive computational methods to model this phenomenon. Here, we introduce HLApollo, a transformer-based model for peptide-MHC-I (pMHC-I) presentation prediction, leveraging the language of peptides, MHC, and source proteins.

Fundus Curvature as a Clinical Marker for Posterior Staphyloma Based on Widefield Optical Coherence Tomography.

Purpose: To investigate the ability to quantify fundus curvature and detect posterior staphyloma using widefield optical coherence tomography (OCT).

Design: Cross-sectional diagnostic evaluation.

Methods: This study reviewed 205 highly myopic eyes of 205 participants.

High-level nitrogen removal achieved by Feammox-based autotrophic nitrogen conversion.

Anaerobic ammonium oxidation coupled with Fe(III) reduction (Feammox) is an essential process in the geochemical iron and nitrogen cycling. This study explores Feammox-based nitrogen removal in a continuous laboratory up-flow bioreactor stimulated by intermittently adding 5 mM Fe(OH) at intervals of approximately two months. The feed was synthetic wastewater with a relatively low ammonium concentration (∼100 mg N/L), yet without organic carbon in order to test its autotrophic nitrogen removal performance.

Achieving mainstream nitrogen removal by partial nitrification and anammox in the carriers-coupled membrane aerated biofilm reactor.

The integration of partial nitrification-anammox (PN/A) into membrane-aerated biofilm reactor (MABR) is a promisingly energy-efficient and high-efficiency technology for nitrogen removal. The inhibition of nitrite oxidizing bacteria (NOB) remains as the most significant challenge for its development. In our investigation, we proposed a novel process to integrate carriers to MABR (CMABR), which combined the carriers enriched with anaerobic ammonium-oxidizing bacteria (AnAOB) and partial nitrifying MABR system.

Effects of preimplantation genetic testing for aneuploidy on embryo transfer outcomes in women of advanced reproductive age with no more than three retrieved oocytes.

Objective: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) benefits women of advanced reproductive age (≥38 years old) with a diminished ovarian reserve (not more than three retrieved oocytes).

Design: A retrospective analysis comparing two groups: (a) PGT-A group: women who chose PGT-A and subsequent single re-warmed embryo transfers and (b) non-PGT-A group: women who chose not to genetically test their embryos and underwent subsequent fresh or re-warmed embryo transfers of one to two embryos on days 3 or 5.

Subjects: Two hundred thirty patients underwent PGT-A therapy, with 49 of these individuals undergoing more than one PGT-A cycle.

[Pollution Characteristics and Risk Assessment of Microplastics in the Xiamen Houxi River Watershed].

Microplastics, defined as minuscule plastic particles measuring less than five millimeters （5 mm） in size, have become pervasive in various environments. Watershed areas, perpetually subjected to escalating human activities, face a growing and persistent threat from microplastic pollution. This study aimed to investigate the characteristics and ecological risk posed by microplastic pollution in the Houxi River watershed of Xiamen.

A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics.

Existing microbiota databases are biased toward adult samples, hampering accurate profiling of the infant gut microbiome. Here, we generated a metagenome-assembled genome inventory for children (MAGIC) from a large collection of bulk and viral-like particle-enriched metagenomes from 0 to 7 years of age, encompassing 3,299 prokaryotic and 139,624 viral species-level genomes, 8.5% and 63.

The Effect of Lifestyle Coaching Design on Patient Engagement and Weight Loss in Non-diabetic Patients of a Semaglutide-Supported Digital Obesity Program in the UK: A Comparative Retrospective Cohort Study.

Digital weight-loss services (DWLSs) that supplement continuous lifestyle coaching with semaglutide therapy have shown promise in delivering continuous and effective obesity care. However, the extent to which lifestyle coaching design influences patient engagement and program effectiveness is unknown. This study retrospectively analysed several engagement markers and weight loss percentage over 16 weeks in a large semaglutide-supported DWLS in the UK (n=154).

A hybrid oxidation approach for converting high-strength urine ammonia into ammonium nitrate.

Nutrient resources contained in human urine have great potential to alleviate global agricultural fertilizer demand. Microbial nitrification is a recognized strategy for stabilizing urine ammonia into ammonium nitrate, a common fertilizer worldwide, but faces a core bottleneck of process instability due to microbial inhibition. This study reports a new approach by developing a hybrid oxidation process involving three stages-microbial ammonia oxidation, chemical nitrite oxidation and microbial nitrite oxidation.

Middle Meningeal Artery Embolization for Nonacute Subdural Hematoma.

Background: The effect of embolization of the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.

Methods: We performed a multicenter, open-label, randomized trial in China, involving patients with symptomatic nonacute subdural hematoma with mass effect. Patients were assigned to undergo burr-hole drainage or receive nonsurgical treatment at the surgeon's discretion, and patients in each group were then randomly assigned, in a 1:1 ratio, to undergo middle meningeal artery embolization with liquid embolic material or to receive usual care.

Most Athletes Who Fail to Return to Sport After Latarjet Procedure Cite Psychological Factors: A Systematic Review.

Purpose: To identify the return-to-sport (RTS) rate in athletes undergoing a Latarjet procedure while outlining the specific reasons for failure to RTS.

Methods: An electronic literature search was conducted (PubMed/MEDLINE, Scopus, Web of Science). Studies in peer-reviewed journals with Latarjet procedures performed on athletes that reported rates and reasons for failure to RTS were included.

Gas-delivery membrane as an alternative aeration method to remove dissolved methane from anaerobically treated wastewater.

Dissolved methane is a hurdle for anaerobic wastewater treatment, which would be stripped into the atmosphere by conventional bubble aeration and increase the release of greenhouse gases into the environment. The high oxygen transfer efficiency and less turbulence in membrane aerated biofilm reactor (MABR) could prevent the stripping of dissolved methane. In this study, an MABR was established to remove dissolved methane aerobically in parallel to the nitrogen removal driven by the anammox process.

The perceptual distinctiveness of the [n-l] contrast in different vowel and tonal contexts.

This study investigates the relative perceptual distinction of the [n] vs [l] contrast in different vowel contexts ([_a] vs [_i]) and tonal contexts (high-initial such as HH, HL, vs low-initial such as LL, LH). The results of two speeded AX discrimination experiments indicated that a [n-l] contrast is perceptually more distinct in the [_a] context and with a high-initial tone. The results are consistent with the typology of the [n] vs [l] contrast across Chinese dialects, which is more frequently observed in the [_a] context and with a high-initial tone, supporting a connection between phonological typology and perceptual distinctiveness.

Stable partial nitrification was achieved for nitrogen removal from municipal wastewater by gel immobilization: A pilot-scale study.

As an energy and carbon saving process for nitrogen removal from wastewater, the partial nitrification and denitrification process (PN/D) has been extensively researched. However, achieving stable PN in municipal wastewater has always been challenging. In this study, a gel immobilized PN/D nitrogen removal process (GI-PN/D) was established.