Numerical simulation of ultrawideband supercontinuum generation covering a 2-20 µm waveband in cascaded all-soft-glass fiber.

We designed a cascaded all-soft-glass fiber structure and simulate midinfrared 2-20 µm ultrawideband supercontinuum (SC) generation numerically. The cascaded fiber structure consists of a 1.5 m fiber, a 0.

Enhancing Heat Transfer Behaviour of Ethylene Glycol by the Introduction of Silicon Carbide Nanoparticles: An Experimental and Molecular Dynamics Simulation Study.

As the critical component of automotive engine coolant, ethylene glycol (E.G.) significantly matters in heat dissipation.

Efficacy comparison of tisagenlecleucel vs usual care in patients with relapsed or refractory follicular lymphoma.

The ELARA trial indicates tisagenlecleucel (tisa-cel) is an effective anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory follicular lymphoma (r/r FL). As ELARA is a single-arm trial, this study compares tisa-cel outcomes from the ELARA trial with usual care from a real-world cohort. ELARA enrolled 98 patients as of 29 March 2021 (median follow-up: 15 months from enrollment).

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages.

SARS-CoV-2 Omicron sublineages carry distinct spike mutations and represent an antigenic shift resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters result in potent plasma neutralizing activity against Omicron BA.1 and BA.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift.

The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in the spike protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody-based therapeutics. Here we show that the Omicron RBD binds to human ACE2 with enhanced affinity, relative to the Wuhan-Hu-1 RBD, and binds to mouse ACE2. Marked reductions in neutralizing activity were observed against Omicron compared to the ancestral pseudovirus in plasma from convalescent individuals and from individuals who had been vaccinated against SARS-CoV-2, but this loss was less pronounced after a third dose of vaccine.

Nitrogen and fluorine co-doped green fluorescence carbon dots as a label-free probe for determination of cytochrome c in serum and temperature sensing.

As an important biomarker, the analysis of cytochrome c (Cyt c) plays a crucial role in cell-apoptosis or even cancer diagnosis. This work develops a label-free probe for Cyt c using the nitrogen and fluorine co-doped carbon dots (N, F-CDs) which were facile prepared through solvothermal method with 3, 4-difluorophenylhydrazine as precursor. The N, F-CDs have an average diameter of 3.

Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis.

Background: Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined.

Methods And Results: The International Collaboration on Endocarditis-PLUS (ICE-PLUS) is a prospective cohort of consecutively enrolled patients with definite IE from 29 centers in 16 countries. We included patients from ICE-PLUS with definite left-sided, non-cardiac device-related IE who were enrolled between September 1, 2008, and December 31, 2012.

Lifetime of ligand-receptor clusters under external force.

We present a theory for the lifetime T(N,f) of a ligand-receptor cluster with N bonds under constant external force F=fN , where f is force per bond. We show that there exists a critical force per bond f(c) such that at large N when f>f(c) the lifetime T(N,f) is independent of cluster size N ; when f>f(c) the lifetime scales as ln[T(N,f)] approximately N due to a free energy barrier with height approximately N along the dissociation path; when f=f(c), the lifetime scales as T(N,f) approximately N(1/3) due to strong fluctuation of a number of closed bonds. Our study shows that adhesion clusters with more bonds are more stable at small f but respond to external force as fast as smaller adhesion clusters at large f .