Disease-Modifying Treatments for Multiple Sclerosis Affect Measures of Cellular Immune Responses to EBNA-1 Peptides.

Background And Objectives: Epstein-Barr virus (EBV) has been strongly implicated in the pathogenesis of multiple sclerosis (MS). Despite this, there are no routinely used tests to measure cellular response to EBV. In this study, we analyzed the cellular response to EBV nuclear antigen-1 (EBNA-1) in people with MS (pwMS) using a whole blood assay.

Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy.

In people living with HIV (PLWH) on antiretroviral therapy (ART), virus persists in a latent form where there is minimal transcription or protein expression. Latently infected cells are a major barrier to curing HIV. Increasing HIV transcription and viral production in latently infected cells could facilitate immune recognition and reduce the pool of infected cells that persist on ART.

A Global Meta-Analysis of Grazing Impacts on Soil Health Indicators.

Grazing lands support the livelihoods of millions of people across nearly one-half of the globe. Soils are the backbone of stability and resilience in these systems. To determine livestock grazing impacts on soil health, we conducted a global meta-analysis of soil organic carbon (SOC), total N, C/N ratio, and bulk density responses to grazing strategies (continuous, rotational, and no grazing) and intensities (heavy, moderate, and light grazing) from 64 studies around the world.

Accurate measurement of (3)J(HNHα) couplings in small or disordered proteins from WATERGATE-optimized TROSY spectra.

Provided that care is taken in adjusting the WATERGATE element of a (1)H-(15)N TROSY-HSQC experiment, such that neither the water magnetization nor the (1)H(α) protons are inverted by its final 180° pulse, (3)JHNHα couplings can be measured directly from splittings in the (1)H dimension of the spectrum. With band-selective (1)H decoupling, very high (15)N resolution can be achieved. A complete set of (3)JHNHα values, ranging from 3.

Correlates of intimate partner violence among female patients at a North Carolina emergency department.

Objective: This paper identifies comorbid factors among female emergency department (ED) patients who have experienced intimate partner violence (IPV).

Methods: 321 adult female patients completed self-administered questionnaires while in an urban North Carolina emergency department. IPV was assessed by questioning whether the patient had ever been afraid of a partner, physically hurt or threatened by a partner, or forced to have sex by a partner.