Publications by authors named "N van Loon"
Article Synopsis
- - Multicellular tumor spheroids are 3D tissue models that mimic the tumor microenvironment, which helps in drug testing and development using bio- and nanosensors.
- - These spheroids have important characteristics like consistent size and growth, but their production methods can lead to variability that affects cell behavior and drug response.
- - The text discusses different spheroid formation protocols and evaluates their compatibility with advanced imaging techniques such as fluorescence lifetime imaging microscopy (FLIM) for studying various cancer and stem cell spheroids.
Introduction: In the Netherlands, most emergency department (ED) patients are referred by a general practitioner (GP) or a hospital specialist. Early risk stratification during telephone referral could allow the physician to assess the severity of the patients' illness in the prehospital setting. We aim to assess the discriminatory value of the acute internal medicine (AIM) physicians' clinical intuition based on telephone referral of ED patients to predict short-term adverse outcomes, and to investigate on which information their predictions are based.
View Article and Find Full Text PDFTandem photovoltaics applying perovskite on silicon are considered to be a possible route to sustaining continuous efficiency improvements and price reductions. A meaningful market share for such tandems is, however, at least a decade away. Herein, a comprehensive prospective life cycle assessment was conducted, comparing the full life cycle of monofacial and bifacial silicon/perovskite tandem panels with single-junction silicon panels produced up to 2050.
View Article and Find Full Text PDFBackground: Type I interferons (IFNs) promote the expansion of subsets of CD1c+ conventional dendritic cells (CD1c+ DCs), but the molecular basis of CD1c+ DCs involvement in conditions not associated without elevated type I IFNs remains unclear.
Methods: We analyzed CD1c+ DCs from two cohorts of non-infectious uveitis patients and healthy donors using RNA-sequencing followed by high-dimensional flow cytometry to characterize the CD1c+ DC populations.
Results: We report that the CD1c+ DCs pool from patients with non-infectious uveitis is skewed toward a gene module with the chemokine receptor as the key hub gene.
Background: Nursing home residents, a frail and old population group, respond poorly to primary mRNA COVID-19 vaccination. A third dose has been shown to boost protection against severe disease and death in this immunosenescent population, but limited data is available on the immune responses it induces.
Methods: In this observational cohort study, peak humoral and cellular immune responses were compared 28 days after the second and third doses of the BNT162b2 mRNA COVID-19 vaccine in residents and staff members of two Belgian nursing homes.