Publications by authors named "N de la Rey"
Objective: The study aimed to evaluate the frequency of pathogenic copy number variants (CNVs) classified as incidental findings (IFs) in prenatal diagnosis and to develop consensus recommendations for standardizing their reporting across six centers within the Catalan public health system (XIGENICS network).
Method: A retrospective review of 4219 consecutive prenatal microarrays performed within the network from 2018 to 2023 was conducted, including all referral reasons. To develop consensus recommendations, several discussion meetings were held along with an extensive review of the existing literature.
Article Synopsis
- The study aimed to evaluate the effectiveness of two indicators, pulmonary artery pulse pressure indexed (PAPi) and radial artery pulse pressure (rPP), in predicting the success of weaning patients off venoarterial extracorporeal membrane oxygenation (VA-ECMO) used for cardiogenic shock.
- Conducted as a retrospective cohort study at a single tertiary hospital, researchers analyzed data from patients who received VA-ECMO between 2017 and 2021 and explored the relation between these pressures and weaning outcomes.
- Results showed that higher values of PAPi and rPP were significantly correlated with successful weaning, indicating that these measurements could serve as reliable predictors for clinicians managing VA-ECMO patients.
The differential vulnerability of dopaminergic neurons of the substantia nigra pars compacta (SNc) is a critical and unresolved question in Parkinson´s disease. Studies in mice show diverse susceptibility of subpopulations of nigral dopaminergic neurons to various toxic agents. In the primate midbrain, the molecular phenotypes of dopaminergic neurons and their differential vulnerability are poorly characterized.
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- * Experts at the 2023 Asia Pacific meeting discussed the risks of gastrointestinal bleeding associated with NOACs, highlighting the need for careful patient monitoring and dosage choices.
- * Edoxaban is noted for its lower risk of gastrointestinal bleeding in Asian patients, making it a strong option for certain individuals needing anticoagulation therapy.
Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD), while those in the dorsal tier and ventral tegmental area are relatively spared. The factors determining why these neurons are more vulnerable than others are still unrevealed. Neuroinflammation and immune cell infiltration have been demonstrated to be a key feature of neurodegeneration in PD.
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