Adaptive Behaviors, Esophageal Anxiety and Hypervigilance Modify the Association Between Dysphagia Perception and Histological Disease Activity in Eosinophilic Esophagitis.

Background Aims: Esophageal symptom-specific anxiety, hypervigilance, and adaptive behaviors at mealtime may affect dysphagia reporting in patients with eosinophilic esophagitis (EoE) but this has not been investigated. Moreover, the relationship between such confounding factors and histological disease activity (HDA) is unclear.

Methods: This was a prospective study on adults with EoE.

Topical Protection of Esophageal Mucosa as a New Treatment of GERD.

Among the various factors implicated in the pathogenesis of gastroesophageal reflux disease (GERD), visceral hypersensitivity and mucosal resistance have been recently re-evaluated in relation to the increasing phenomenon of proton pump inhibitor failure, particularly in patients with nonerosive reflux disease (NERD). Intensive research has allowed us to understand that noxious substances contained in the refluxate are able to interact with esophageal epithelium and to induce the elicitation of symptoms. The frequent evidence of microscopic esophagitis able to increase the permeability of the mucosa, the proximity of sensory afferent nerve fibers to the esophageal lumen favoring the higher sensitivity to noxious substances and the possible activation of inflammatory pathways interacting with sensory nerve endings are pathophysiological alterations confirming that mucosal resistance is impaired in GERD patients.

The Milan Score Predicts Objective Gastroesophageal Reflux Disease in Patients With Type 2 Esophagogastric Junction.

Introduction: High-resolution manometry (HRM) allows assessment of esophagogastric junction (EGJ) disruption. While type 3 EGJ predicts definitive gastroesophageal reflux disease (GERD), type 2 EGJ is less clearly implicated in GERD pathogenesis. This study aimed to characterize physiologic findings in type 2 EGJ to determine if the HRM-based Milan Score can define GERD within type 2 EGJ.

Biomechanical Finite Element Analysis of Two Types of Short-Angled Implants Across Various Bone Classifications.

The aim of this finite element analysis (FEA) was to investigate the distribution of von Mises stress within dental implant components, as well as trabecular and cortical bone. The study considered various bone qualities that influence cortical thickness in contact with the implant, specifically examining cortical thicknesses of 0.5, 1.