[A unified digital circuit in ensuring operative monitoring of carbohydrate metabolism in middle, elderly and senile aged people in the conditions of a new coronavirus infection.].

One of the positive aspects of the implementation of laboratory information systems (LIS) in a medical organization, according to the plan of the Federal project of the Ministry of Health of the Russian Federation to create a unified digital circuit in healthcare, is the emergence of the ability to download large amounts of laboratory research data and analyze them. The purpose of the work is to assess the possibility of a unified digital circuit in providing operational monitoring of carbohydrate metabolism in middle-aged, elderly and senile people in the context of COVID-19. The materials used are the primary data of laboratory research results from the LIS «Ariadna.

[A portrait of a doctor with Parkinson's disease].

In a number of causes of Parkinson's disease (PD), occupation is periodically mentioned as a possible risk factor. However, a look at the complex impact of external factors on people of certain professions and the expansion of the area of risk factors in a rapidly changing world leads to the emergence of new studies. There is an assumption that the risk of developing PD is increased in doctors due to long-term exposure to stress.

Triple combination of vemurafenib, cobimetinib, and atezolizumab in real clinical practice in the Russian Federation: results of the A1 cohort of the ISABELLA study.

Background: Among several treatment options for BRAF-mutant metastatic melanoma, a combination of BRAF inhibitor, MEK inhibitor, and anti-PDL1 antibody seems to be a new emergent approach recently registered in the Russian Federation. It is still not clear which patient population benefits more from this simultaneous use of three drugs instead of its sequencing.

Aim: This study aimed to evaluate patients' characteristics treated in real practice in 14 Russian regions by triple combination and to analyze their outcomes depending on biomarkers (PD-L1 expression).

[Sarcopenia as a non-motor symptom of Parkinson's disease].

Sarcopenia is a progressive generalized skeletal muscle disease that is accompanied by an accelerated loss of muscle mass and function, affecting the quality of life and the ability to perform self-care. The prevalence of sarcopenia in the world today ranges from 10 to 25%, which represents a certain danger as it is a prognostic factor for possible injury and increased disability in the elderly population. Sarcopenia often accompanies a large number of different diseases, including neurodegenerative ones, so it is actively studied in this category of patients, for example, as one of the early symptoms of Parkinson's disease (PD).

AcOH-Catalyzed Rearrangements of Benzo[][1,4]diazepin-2(and 3)-ones: Easy Access to 1,4-Dihydroquinazolines and Their Condensed Analogues.

Presented herein is a novel synthesis of new 2-(quinolin-4-yl)-1,4-dihydroquinazoline systems , in which the acid-catalyzed rearrangement of spiro[benzo[][1,4]diazepine-3,4'-quinolin]-2(1)-ones generated from 3-(2-aminophenyl)-5-benzo[][1,4]diazepin-2(1)-ones with acetone and alkylmethyl ketones has been realized as an important step. An attempt to synthesize isomeric 2-(2-aminophenyl)-5-benzo[][1,4]diazepin-3(4)-one by hydrolysis of the corresponding -{2-[5-benzo[][1,4]diazepin-3(4)-on-2-yl]phenyl}acetamide led to a new heterocyclic system, 6-methyl-8,13-dihydro-13a-quinazolino[4,3-]quinazolin-5-ium 13a-carboxylate , as a result of an unexpected rearrangement. In addition, it is noteworthy that during the hydrolysis of -{2-[5-benzo[][1,4]diazepin-2(1)-on-3-yl]phenyl}acetamides , the not previously described 14-dihydro-5-14,5a-(epimino[1,2]benzo)benzo[5,6][1,4]diazepin[2,1]quinazolin-6(7)-ones were unexpectedly obtained.