Publications by authors named "N Zgheib"
Article Synopsis
- Antiseizure medications, like valproic acid (VPA), show different results in patients due to genetic factors, though there's limited research specifically on VPA compared to other drugs.
- This study aimed to analyze how genetic variations influence the effectiveness, side effects, and serum levels of VPA in patients with genetic generalized epilepsies (GGE).
- The results revealed that certain genetic variants are linked to treatment failure, increased serum levels, weight gain, and hair loss among GGE patients using VPA, suggesting a need for personalized medication approaches.
Article Synopsis
- Pharmacogenomics (PGx) research in Lebanon is crucial due to the country's genetic diversity and potential for leadership in medicine and education.
- The manuscript reviews current PGx research in Lebanon, discusses the practice and challenges faced, and identifies opportunities for growth and improvement.
- A case study from the American University of Beirut highlights the development of PGx programs, while also addressing the need for increased education and training, including online courses and certifications.
Pharmacogenetic considerations in therapy with novel antiplatelet and anticoagulant agents.
Pharmacogenet Genomics
April 2024
Antiplatelets and anticoagulants are extensively used in cardiovascular medicine for the prevention and treatment of thrombosis in the venous and arterial circulations. Wide inter-individual variability has been observed in response to antiplatelets and anticoagulants, which triggered researchers to investigate the genetic basis of this variability. Data from extensive pharmacogenetic studies pointed to strong evidence of association between polymorphisms in candidate genes and the pharmacokinetics and pharmacodynamic action and clinical response of the antiplatelets clopidogrel and the anticoagulant warfarin.
View Article and Find Full Text PDFTwo hundred and twenty subjects were recruited while undergoing cardiac catheterization. AHRR cg05575921 methylation was shown to be significantly decreased in ever smokers compared to never smokers (Mean± SD = 64.2 ± 17.
View Article and Find Full Text PDFArticle Synopsis
- - The COVID-19 pandemic led to significant changes in medical education delivery, prompting a study to assess these impacts and future directions in the field.
- - Interviews with leaders from 16 US medical schools revealed mixed feelings about online education, highlighting its efficiency but expressing concerns about drawbacks like limited social interaction and challenges in clinical training.
- - Experts suggest a hybrid model moving forward, maintaining online learning for lectures while prioritizing in-person education for skills development, alongside new elements like telemedicine and greater student involvement in patient care.