CARDIOMYOCYTE DNA CONTENT AND ITS LINK TO CSE/ H2S SYSTEM IN THE HEART OF EXPERIMENTAL DIABETIC RATS.

One of the most common complication of diabetes mellitus (DM) is diabetic cardiomyopathy, which is associated with the development of inflammation, fibrosis and the induction of apoptosis. Hydrogen sulfide (H2S) has recently been shown to play an important role in the regulation of cardiac and vascular function. The role of the H2S system in the mechanisms of diabetic heart development remains uncertain.

Circadian Rhythms of Endothelial Nitric Oxide Synthase and Toll-like Receptors 2 Production in Females with Rheumatoid Arthritis Depending on NOS3 Gene Polymorphism.

Background: Rheumatoid Arthritis (RA) is an autoimmune polygenic disease characterized by rapid disability progression and high prevalence. Progression of RA is closely associated with chronobiological changes in the production of some hormones and inflammatory mediators, influencing the disease course and therapy efficacy. The main pathogenetic mechanism of RA is angiogenesis, which is controlled by biological clock-genes.

Antiphospholipid and antineutrophil antibodies levels in men with stable coronary heart disease and postinfarction cardiosclerosis and its relationship with the disease manifestation.

Objective: The aim is to study the levels of antiphospholipid (aPL) and antineutrophil antibodies in men with stable coronary heart disease (CHD) with postinfarction cardiosclerosis and to evaluate its relationship with the disease manifestation.

Patients And Methods: Materials and methods: 164 men with stable CHD and postinfarction cardiosclerosis (53.0 ± 9.

ASSOCIATIONS BETWEEN EFFICACY OF THE THERAPY AND CIRCADIAN FLUCTUATIONS OF ENDOTHELIAL NITRIC OXIDE SYNTHASE WITH TOLL-LIKE RECEPTORS 2 EXPRESSION, AND NOS3 POLYMORPHISM IN FEMALES WITH RHEUMATOID ARTHRITIS.

Despite significant progress in treatment of rheumatoid arthritis (RA), a considerable part of patients remains resistant to the current therapy, apparently for the reasons of undefined mechanisms of its pathogenesis. Recently, the disturbances of circadian regulation of inflammatory processes in RA have been highlighted as important ones. Endothelial nitric oxide synthase (NOS3) and soluble toll-like receptors 2 (sTLR2) take part in the regulation of angiogenesis, osteoclastogenesis, immune responses but their circadian rhythms and predictive significance in RA patients are still unknown.

Circadian fluctuations of endothelial nitric oxide synthase activity in females with rheumatoid arthritis: a pilot study.

Rheumatoid arthritis (RA) is a disease associated with circadian disorders of steroid hormones or cytokine secretion which induce inflammatory, destructive and proliferative processes in the synovial joints. Angiogenesis plays an important role in RA, but circadian rhythms of the angiogenic mediator production, especially endothelial nitric oxide synthase (NOS3), are still unclear. NOS3 takes part in regulation of endothelial functions, inflammation, and bone remodeling process.