[Ultrasound elastography of the liver for assessing the risk of complications of its cirrhosis of different etiologies].

Aim: To study the results of dynamic liver ultrasound elastography (LUE) in assessing the risk of complications of liver cirrhosis (LC) of different etiologies and to elaborate a monitoring program for estimation of the predictive value of elastography in patients with LC.

Subjects And Methods: A total of 194 patients with LC of different etiologies, including 56 patients with alcoholic cirrhosis, 48 with LC and an outcome of nonalcoholic fatty liver disease, 53 with LC and an outcome of chronic hepatitis C, 23 with LC and an outcome of chronic hepatitis B, and 14 with an outcome of coinfection with hepatitis B and D viruses, were examined. An analysis was made between the presence of a number of LC complications and the results of LUE, by constructing the receiver operating characteristic (ROC) curves to select LUE threshold values, in which there was a high risk for LC complications (esophageal varices, bleeding esophageal varices, hepatic encephalopathy, and ascites).

[CLINICAL FEATURE OF NONALCOHOLIC STEATOHEPATITIS, ASSOCIATED WITH CHRONIC CONSTIPATION].

The Aim Of The Study: to conduct a comprehensive assessment of features of combined course NASH and functional constipation using laboratory parameters, the data of instrumental methods, indicators of quality of life in comparison with patients with Nash without proven pathology of the intestine.

Materials And Methods: In the cross-sectional comparative study involving 102 patients with NASH, among which identified patients with functional constipation, there were formed two groups: study group (patients with NASH and functional constipation) and comparison group (patients with NASH without pathology of the intestine). All patients underwent a comprehensive assessment of laboratory data (markers of cytolysis, cholestasis, lipid and carbohydrate metabolism), results of instrumental methods (hydrogen breath test), quality of life (questionnaire SF-36).

[Experience with the use of 13C-breath test for the evaluation of the efficacy of enzyme substitution therapy with microencapsulated pancreatinin in patients with severe primary pancreatic insufficiency].

The aim of the study was to evaluate efficiency of creon substitution therapy of severe primary pancreatic insufficiency in the 13C-breath test. It included 32 patients (mean age 48.2 +/- 6.

[Changes in the functional activity of neutrophils during their interaction with Yersinia pestis in vitro].

The functional state and electrochemical properties of human blood neutrophil leukocytes after their in vitro interaction with Y. pestis cells, strain EV, was analyzed. A considerable decrease in the electrophoretic mobility of neutrophil leukocytes and a considerable increase in their phagocytic indices was shown.

[The effect of Yersinia pestis antigens and strains on the level of lymphocyte blast transformation].

Lymphocytic blast-cell transformation (LBCT) is shown to be related both to the genotype of a macroorganism and to the genetically determined expression of individual antigens by the plague microbe. The correlation of LBCT with the level of antiinfectious resistance suggests that this index is of high informative value and that it can be effectively used for testing the cellular immunity and the characteristically biological properties of the plague causative agent and its antigens.