STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.

STAT5B is a vital transcription factor for lymphocytes. Here, function of two STAT5B mutations from human T cell leukemias: one substituting tyrosine 665 with phenylalanine (STAT5B ), the other with histidine (STAT5B ) was interrogated. modeling predicted divergent energetic effects on homodimerization with a range of pathogenicity.

Outbreak of perichondritis associated with ear piercings and a contaminated water system.

In September 2023, the UK Health Security Agency's (UKHSA) South West Health Protection Team received notification of patients with perichondritis. All five cases had attended the same cosmetic piercing studio and a multi-disciplinary outbreak control investigation was subsequently initiated. An additional five cases attending the same studio were found.

The literature exploring the perspectives and experiences of racialized students in entry-level health professional education programs: a scoping review protocol.

Objective: The objective of this scoping review will be to determine the breadth of literature exploring the perspectives and experiences of racialized students in entry-level health professional education programs.

Introduction: Despite the implementation of equity, diversity, and inclusion (EDI) policies and alternative admission criteria for minority students, racialized minorities continue to be underrepresented and have the highest attrition rate in health professional education programs. Furthermore, the students who eventually work in health care settings report experiences of microaggression and prejudice.

Integrating Implementation Science in Interpersonal Violence Research and Practice: A Systematic Review of Barriers and Facilitators of Implementation.

Despite the prevalence and harmful consequences of interpersonal violence and the growth in intervention research, applying research evidence and strategies into practice remains limited. This systematic review addresses this gap by using the Consolidated Framework of Implementation Research (CFIR) to characterize barriers and facilitators in efforts to prevent and address interpersonal violence. A systematic search of peer-reviewed literature was conducted using the following databases: PubMed, Embase, CINAHL, Cochrane, Web of Science, Scopus, and APA PsycInfo.

Total Prostate-Specific Antigen (PSA) Testing in Capillary Samples: Proof-of-Principle and Feasibility Study for Home Self-Testing for Prostate Cancer.

Background: There is growing interest in the use of capillary blood sampling (CBS) for testing biochemical analytes owing to the advantages it offers including home surveillance of chronic conditions. In this study, we aimed to determine whether the use of CBS was a viable and feasible method for testing total prostate-specific antigen (TPSA) concentrations in men with prostate disease.

Methods: Men with known prostate disease were recruited from a urology clinic where they were being treated or followed up.