Publications by authors named "N Yahata"

Article Synopsis
  • Autism spectrum disorder (ASD) is a complex lifelong condition, and this study aimed to create a classifier using resting-state fMRI from a large group of 730 Japanese adults to identify its neural and biological features.
  • The developed classifier showed effectiveness in differentiating individuals with ASD from neurotypical controls across various countries, including the US and Belgium, and it also applied to children and adolescents.
  • Importantly, the study found that the classifier identified crucial functional connections related to social interaction difficulties and neurotransmitter activity, and it linked ASD with similar neurobiological factors seen in ADHD and schizophrenia, enhancing understanding of related mental health disorders.
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Primates must adapt to changing environments by optimizing their behavior to make beneficial choices. At the core of adaptive behavior is the orbitofrontal cortex (OFC) of the brain, which updates choice value through direct experience or knowledge-based inference. Here, we identify distinct neural circuitry underlying these two separate abilities.

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Thalamic pain can be understood as a network reorganization disorder. This study aimed to investigate functional connectivity (FC) in human patients and a macaque model of thalamic pain. In humans, resting-state FC was compared between patients with thalamic pain and healthy individuals.

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Article Synopsis
  • Duplication of chromosome 15q11-13 is linked to autism spectrum disorder (ASD) and was studied in a mouse model known as 15q dup mice.
  • The study involved behavioral tests for anxiety and social interactions, alongside MRI scans, to explore the connection between brain structure and behavior in these mice.
  • Findings showed that 15q dup mice exhibited higher anxiety levels and varied social behaviors, with a correlation found between lower sociability and reduced gray matter in a specific brain region, highlighting the complexities of ASD's behavioral diversity.
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Previous studies reported decreased glutamate levels in the anterior cingulate cortex (ACC) in non-treatment-resistant schizophrenia and first-episode psychosis. However, ACC glutamatergic changes in subjects at high-risk for psychosis, and the effects of commonly experienced environmental emotional/social stressors on glutamatergic function in adolescents remain unclear. In this study, adolescents recruited from the general population underwent proton magnetic resonance spectroscopy (MRS) of the pregenual ACC using a 3-Tesla scanner.

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