Publications by authors named "N Y Uzcategui"
Article Synopsis
- Developing broad-spectrum coronavirus vaccines is crucial for future pandemic preparedness against respiratory viruses.* -
- A trivalent subunit vaccine was created using receptor-binding domains from three coronaviruses: SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5, combined with adjuvants Alum and CpG55.2.* -
- Vaccinated mice showed cross-neutralizing antibodies for all three Betacoronaviruses and some bat-exclusive viruses, suggesting good epitope preservation and potential for broader immune response.*
Introduction: Zebrafishes represent a proven model for human diseases and systems biology, exhibiting physiological and genetic similarities and having innate and adaptive immune systems. However, they are underexplored for human vaccinology, vaccine development, and testing. Here we summarize gaps and challenges.
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- Researchers developed a next-generation SARS-CoV-2 vaccine targeting the XBB variant, building on a previous vaccine that effectively generated high antibody responses against the wild-type virus.
- They tested this new vaccine in mice, using a yeast-produced XBB.1.5 RBD subunit combined with adjuvants, and found it produced strong antibody responses and effective neutralization against various Omicron pseudoviruses.
- Despite the success with Omicron, antibodies produced against the new vaccine showed lower neutralization against earlier variants like wild-type and Delta, indicating the need for updated vaccine formulations that focus on the XBB.1.5 antigen.
Introduction: Invasion of the central nervous system (CNS) is the most serious consequence of infection, which causes sleeping sickness. Recent experimental data have revealed some more insights into the disease during the meningoencephalitic stage. However, detailed cellular processes befalling the CNS during the disease are poorly understood.
View Article and Find Full Text PDFChagas disease, caused by the kinetoplastid parasite , is a human tropical illness mainly present in Latin America. The therapies available against this disease are far from ideal. Proteases from pathogenic protozoan have been considered as good drug target candidates.
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