Publications by authors named "N Y Ran"
Accurate determination of pesticide residues is crucial for food safety. A self-calibration method was developed for dual-signal "naked-eye" detection of organophosphorus pesticides (OPs) using bifunctional gold nanozymes (AuNEs). OPs inhibit the cascade reaction of acetylcholinesterase/choline oxidase (AChE/CHO) to reduce hydrogen peroxide (HO) production, which affects the AuNE-catalyzed color reaction and quenches the fluorescence of AuNEs with the assistance of Fe.
View Article and Find Full Text PDFSelf-healing hydrogels have attracted significant attention in chronic diabetic wound healing due to their potential to minimize the risk of secondary infections caused by joint movement or dressing rupture. Herein, a multifunctional self-healing hydrogel mediated utilizing an enzyme-triggered cascade reaction based on dynamic imine bonds was designed. The hydrogel employs three enzymes: lysozyme (LYZ), glucose oxidase (GOx), and catalase (CAT), as building blocks.
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- Ischemic stroke is the most common type of stroke, and ACSL4 plays a role in ischemia/reperfusion, but its impact on lower limb neurological issues post-stroke hasn't been studied until now.
- This study aimed to assess how ACSL4 levels and collateral circulation predict lower limb function in ischemic stroke patients undergoing modified constraint-induced movement therapy (mCIMT).
- Results showed that higher ACSL4 at admission correlated with worse lower limb motor function, while collateral circulation grading helped predict recovery outcomes, indicating both factors could be useful in patient prognosis.
Article Synopsis
- Activation of endogenous neural stem cells (NSCs) can promote healing after spinal cord injuries, but methods to regulate these cells are limited.
- This study found that nicotinamide riboside enhances the growth of NSCs and helps them differentiate into neurons, leading to improved lower limb motor function after injury.
- The mechanism behind this involves the activation of the Wnt signaling pathway through the LGR5 gene, as blocking this pathway hinders the effects of nicotinamide riboside on NSC proliferation.