Antibiotic resistance patterns in Pseudomonas aeruginosa: an 8-year surveillance study in a French hospital.

The susceptibility to ticarcillin, piperacillin, ceftazidime, aztreonam, tobramycin, amikacin, ciprofloxacin and fosfomycin of 3876 strains of Pseudomonas aeruginosa isolated during the period 1989-1996 in a French hospital was investigated. The most frequently active agents were amikacin and ceftazidime to which 13.3% and 16.

Viridans group streptococci: an underestimated cause of spontaneous bacterial peritonitis in cirrhotic patients with ascites.

Objectives: The objective of the study was to examine the characteristics of spontaneous bacterial peritonitis (SBP) caused by streptococci, in particular viridans group streptococci (VGS), and to investigate a potential association between the long-term administration of norfloxacin and high-level resistance to fluoroquinolones in these organisms.

Methods: We reviewed 84 episodes of SBP and bacterascites caused by streptococci that occurred in 75 patients over a 6-year period. Isolates were tested for antibiotic susceptibility by the determination of minimum inhibitory concentrations.

Comparative activity of beta-lactam agents (carbapenem excepted) against Pseudomonas aeruginosa strains with CARB or OXA beta-lactamases.

Background: Ticarcillin resistance in Pseudomonas aeruginosa can be mediated by various beta-lactamases of the CARB and OXA groups.

Methods: We investigated the activity of seven beta-lactam agents and two beta-lactam-beta-lactamase inhibitor combinations against 216 P.aeruginosa strains with genotypically characterized beta-lactamases, including 137 CARB, 31 OXA-35, 25 OXA-10, 13 OXA-1 and 10 OXA-2.

Nosocomial and community-acquired spontaneous bacterial peritonitis: comparative microbiology and therapeutic implications.

In order to compare the microbiological characteristics of nosocomial and community-acquired episodes of bacterial peritonitis, 95 consecutive, spontaneous episodes were reviewed. Seventy of these episodes were bacteriologically documented. Fifty-three (55.

Identification of PSE and OXA beta-lactamase genes in Pseudomonas aeruginosa using PCR-restriction fragment length polymorphism.

Objective: A method using PCR-restriction fragment length polymorphism was developed to identify Pseudomonas aeruginosa beta-lactamase genes.

Methods: Two hundred and fifty-nine P. aeruginosa isolates were screened by PCR with 11 primer pairs designed to detect genes encoding PSE, OXA, TEM and SHV enzymes.